Results 141 to 150 of about 10,543,759 (362)

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

open access: yesMolecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li   +12 more
wiley   +1 more source

The Human Being's Role in the Process of Epistemological Effectiveness of the Social Factors [PDF]

open access: yesIslām va ̒ulūm-i ijtimā̒ī
The human being is a social creature whose perfections grow in the context of sociallife and that is why he/she deals with the social factors continually.
Ghodratollah Ghorbani
doaj  

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

open access: yesMolecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi   +12 more
wiley   +1 more source

Learning to detect unseen object classes by between-class attribute transfer

open access: yes2009 IEEE Conference on Computer Vision and Pattern Recognition, 2009
Christoph H. Lampert   +2 more
semanticscholar   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

open access: yesMolecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza   +3 more
wiley   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

open access: yesMolecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh   +5 more
wiley   +1 more source

A orkutização das marcas: Disputas midiatizadas de distinção e pertencimento entre as classes sociais

open access: yesSignos do Consumo, 2014
O presente estudo visa entender como as classes estão em conflito no meio social e têm nas marcas o ápice dessas disputas distintivas midiatizadas. Tal fenômeno tem ligação com a distinção das marcas por um núcleo pequeno e elitista da sociedade versus a
Alhen Rubens Silveira Damasceno   +1 more
doaj  

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