Results 141 to 150 of about 1,047,062 (258)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Schedule of Classes [University of North Texas]
, 2001 Schedule of classes at the University of North Texas for the Summer semester providing a list of classes that will be offered by department, with times and locations.
University of North Texas. Office of University Communications and Marketing. +1 more
core
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2009 This research was conducted in 2007 on Cyprinus carpi° in Alvand High School in Ghasreshirin. We randomly selected 20 broodstock male fishes in 2 age classes (2+, 3+ years old). In each year class, 10 males were selected and after sperm striping, seminal
Sh. Hosseini; R. Lorestani
doaj
, 2014 Le 26 mai s'est tenue une journée d'études sur les classes sociales organisée par Isabelle Clair (Cresppa-GTM), Danièle Kergoat (Cresppa-GTM) et Cédric Lomba (Cresppa-CSU).
fannygallot
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Schedule of Classes [University of North Texas]
, 2002 Schedule of classes at the University of North Texas for the Summer semester providing a list of classes that will be offered by department, with times and locations.
University of North Texas. Office of University Communications and Marketing. +1 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
DaimonEn el presente artículo se exponen las diferentes teorías de las propiedades realizadas desde el nominalismo estricto y apuntamos los problemas fundamentales de las mismas.
Joan Pagès
doaj