Results 221 to 230 of about 235,773 (256)

Multifunctional Bioactive Scaffold Facilitating BMSCs‐Driven Osteogenesis and Vascularization in Critical‐Sized Bone Defect Repair

Advanced Science, EarlyView.
A dual‐network bFGF@CB‐gel integrates: i) ChSMA scaffold (mechanical support/BMSCs delivery); ii) BC carrier (sustained bFGF release via EGFL/Itga2b and COMP/PI3K/AKT for adhesion/osteogenesis); iii) bFGF/PI3K/AKT/eNOS for angiogenesis. This rational, synergistic design addresses CSD bone regeneration challenges.
Yunze Feng, Bingzhi Chen, Yu Xu, Xin Xu, Bingtao Hu, Tongbo Li, Dingxin Zhang, Baoshuai Bai, Chen Liu, Wanlong Xu, Le Li, Wencan Zhang, Haipeng Si   +12 more
wiley   +1 more source

Research methodologies in genetic counseling: Grounded theory. [PDF]

J Genet Couns
Fishler Malone K, Carmichael N.
europepmc   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

The effectiveness and mechanisms of a filmmaking intervention for adolescent aggression: a mixed methods study. [PDF]

Child Adolesc Psychiatry Ment Health
Zhang Y, Fung ALC, Liang Y, Sun Q, Ni S.
europepmc   +1 more source

Polyelectrolyte Design Principles for Electrophoretic Drug Delivery

Advanced Science, EarlyView.
Structure–property–function mapping of polyelectrolytes reveals how composition and nanoscale order control on‐demand electrophoretic drug transport. Charge density quantified under implant‐relevant conditions shows that encapsulation limits swelling, enabling high effective charge density.
Helena Saarela Unemo, Iwona Bernacka‐Wojcik, Lingkai Zhu, Marle E. J. Vleugels, Moa E. Hörberg, Caroline Lindholm, Magnus Berggren, Daniel T. Simon, Theresia Arbring Sjöström   +8 more
wiley   +1 more source

Beyond concreteness: why word specificity is the missing piece in theories on embodied language comprehension. [PDF]

Front Psychol
Bolognesi M.
europepmc   +1 more source

Passing ethnographies: rethinking the sites of agency and reflexivity in a mediated world [PDF]

, 2003
Couldry, Nick
core  

From mechanisms to meanings: toward a content-sensitive psychiatry. [PDF]

Front Psychiatry
Ferrer Nappe L.
europepmc   +1 more source

Identity and theatre translation in Hong Kong. By Shelby Kar-yan Chan

, 2016
LIM, Wah Guan
core  

When Rituals Fail: Rationalization, Bayesianism, and Predictive Processing. [PDF]

Evol Anthropol
Hong Z.
europepmc   +1 more source