Results 121 to 130 of about 6,056,592 (368)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

THE ROLE OF RATIONALITY PHILOSOPHY IN LEGAL STUDIES (PART II)

open access: yesRUDN Journal of Law, 2019
The relevance of the article, which consists of two parts, is that the various theories of rationality presented only in philosophical works are considered.
Valeriy P. Ivanskiy, Sergey I. Kovalev
doaj   +1 more source

Classical Extensions, Classical Representations and Bayesian Updating in Quantum Mechanics

open access: yes, 2004
I review the formalism of classical extensions of quantum mechanics introduced by Beltrametti and Bugajski, and compare it to the classical representations discussed e.g.
Bacciagaluppi, Guido
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Vibrio cholerae Pathogenic Clones

open access: yesEmerging Infectious Diseases, 2005
We resolved the relationships between 2 pandemic clones of Vibrio cholerae. Using 26 housekeeping genes, we showed that the US Gulf clone, the Australian clone, and 3 El Tor strains isolated before the seventh pandemic were related to the seventh ...
Anna Salim, Ruiting Lan, Peter R. Reeves
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

The European Union summary report on surveillance for the presence of transmissible spongiform encephalopathies (TSE) in 2023

open access: yesEFSA Journal
This report presents the results of surveillance on transmissible spongiform encephalopathies in cattle, sheep, goats, cervids and other species, and genotyping in sheep and goats, carried out in 2023 by 27 Member States (MS, EU27), the United Kingdom ...
European Food Safety Authority (EFSA)
doaj   +1 more source

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