Results 111 to 120 of about 11,504,041 (312)

Black hole thermodynamics: general relativity and beyond

open access: yes, 2019
Black holes have often provided profound insights into the nature of gravity and the structure of space–time. The study of the mathematical properties of black objects is a major research theme of contemporary theoretical physics.
Sarkar, Sudipta, Sudipta Sarkar
core   +1 more source

A Primer on Spacetime Singularities I: Mathematical Framework

open access: yesUniverse
This article presents a comprehensive and rigorous overview of spacetime singularities within the framework of classical General Relativity. Singularities are defined through the failure of geodesic completeness, reflecting the limits of predictability ...
Jean-Pierre Luminet
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

open access: yesFEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki   +5 more
wiley   +1 more source

Take a Ride on a Time Machine [PDF]

open access: yes, 2003
We discuss the possibility to build and operate a time machine, a device that produces closed timelike curves (CTCs). We specify the spacetime structure needed to implement a time machine and assess attempted no-go results against time machines in ...
Wuthrich, Christian   +2 more
core  

Theoretical Physics: A Primer for Philosophers of Science

open access: yesPrincipia: An International Journal of Epistemology, 2009
We give a overview of the main areas in theoretical physics, with emphasis on their relation to Lagrangian formalism in classical mechanics. This review covers classical mechanics; the road from classical mechanics to Schrödinger’s quantum mechanics ...
Francisco Antonio Doria
doaj  

Ashtekar variables in classical general relativity [PDF]

open access: yes, 2008
31 Pages, Plain-Tex; Further comments were added, minor grammatical changes made and typos ...
openaire   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng   +4 more
wiley   +1 more source

Electron Spin or ``Classically Non-Describable Two-Valuedness'' [PDF]

open access: yes, 2007
In December 1924 Wolfgang Pauli proposed the idea of an inner degree of freedom of the electron, which he insisted should be thought of as genuinely quantum mechanical in nature.
Domenico Giulini   +2 more
core   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket   +14 more
wiley   +1 more source

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