Results 21 to 30 of about 1,142 (91)

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

Multi‐omics reveals a novel Cxcr4+ subpopulation of alveolar macrophages and therapeutic effect of AMD3100 in mice with advanced silicosis

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
The progression of silicosis‐associated fibrosis relies on a positive feedback loop mediated by crosstalk between Cxcr4+ macrophages and Cxcl12+ fibroblasts and the therapeutic potential of targeting the Cxcl12/Cxcr4 axis with AMD3100 as a novel strategy for treating silicosis.
Min Mu, Bing Li, Hangbing Cao, Yuanjie Zou, Ruiqing Yan, Fei Wang, Yehong Zhao, Zihao Xie, Miaomiao Du, Xiaolong Wu, Xinrong Tao, Jianhua Wang   +11 more
wiley   +1 more source

Enteromorpha prolifera Polysaccharide Alleviates Type 2 Diabetes via the Gut Microbiota–Liver Axis to Modulate Cholesterol Metabolism

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Enteromorpha prolifera polysaccharides may help restore lipid metabolism homeostasis by gently remodeling the gut microbiota to enrich beneficial bacteria and SCFAs, which in turn appears to modulate hepatic functions through the portal vein by downregulating cholesterol synthesis and promoting its metabolism. This coordinated process potentially leads
Liuying Zhu, Xusheng Wen, Wenrong Zhu, Xueqian Hu, Yanqun Xu, Xin Peng   +5 more
wiley   +1 more source

A Balancing Act in Corneal Epithelial Repair: A MAPK-JUN/EGR1/TFAP2A Network Regulates Ferroptotic Cell Fate. [PDF]

Int J Gen Med
Jiang H, Chen Z, Luan W, Li J, Yin N.
europepmc   +1 more source

An ITGA11 expressing subpopulation as predictor for the donor-specific osteogenic capacity of stromal cells. [PDF]

Bone Res
Jamil AJM, Madsen K, Daamouch S, Villadsen B, Ma C, Jeromdesella S, Nørgård MØ, Grupe E, Jakobsson MB, Wang Y, Takematsu E, Zhao L, Goodman SB, Goodnough LH, Chan CKF, Andersen TL, Kassem M, Rauch A.   +17 more
europepmc   +1 more source

MFAP5⁺ synovial fibroblasts drive LOX upregulation to promote osteoarthritis progression. [PDF]

iScience
Wang L, Wei G, Ma F, Li X, Zhang H, Pan H, Meng Z, Yang S, Yang R, Dong J, Xiong X, Xu Z, Zhang B, Cheng H, Li B, Yang L, E X, Li X.   +17 more
europepmc   +1 more source

Surgery/anesthesia may cause monocytes to promote tumor development. [PDF]

Mol Med
Wang YY, Zhu RL, Chang EQ, Liu XZ, Wang GZ, Li NT, Zhang W, Zhou J, Sun MY, Zou X, Hao J, Zhang JQ.   +11 more
europepmc   +1 more source

Co-Conservation of synaptic gene expression and circuitry in collicular neurons. [PDF]

Nat Commun
Liu Y, McDaniel JA, Chen C, Yang L, Kipcak A, Savier EL, Erisir A, Cang J, Campbell JN.   +8 more
europepmc   +1 more source

Aging reshapes the osteosarcoma ecosystem through immune dysfunction and tumor cell reprogramming. [PDF]

Cell Oncol (Dordr)
Shen R, Chen M, Zhu X, Lin J.
europepmc   +1 more source

Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses. [PDF]

Nat Commun
Bai M, Yin T, Li X, Wang P, Lei T, Jin P, Li F, Guo H, Guo X, Sun X, Li Y, Zou B, Yu J, Liu C, Teng F.   +14 more
europepmc   +1 more source