Results 41 to 50 of about 4,216,905 (267)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Fabric Tensors in Bone Mechanics

Engineering Transactions, 2015
Mechanical properties of cancellous and cortical bone have been investigated. The fabric tensors used in the relevant literature have been discussed. Nonlinear elastic and elastic-perfectly plastic constitutive relationships have been proposed within the
S. Jemioło, J.J. Telega
doaj   +1 more source

Buckling and Vibration Analysis of Tapered Circular Nano Plate [PDF]

Journal of Applied and Computational Mechanics, 2018
In this paper, buckling and free vibration analysis of a circular tapered nanoplate subjected to in-plane forces were studied. The linear variation of the plate thickness was considered in radial direction.
Mehdi Zarei, Gholamreza Faghani, Mehran Ghalami, Gholam Hossien Rahimi   +3 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

THE REFINED THEORY OF ELASTIC PLATES AS ASYMPTOTIC APPROACH OF 3D PROBLEM

MATEC Web of Conferences, 2018
The refined theory of elastic thin and thick plates is constructed by the asymptotic method for reducing three-dimensional (3D) equations of linear elasticity to two-dimensional ones without the use of any assumptions.
Rogacheva Nelly
doaj   +1 more source

Solutions of some boundary value problems for a new class of elastic bodies undergoing small strains. Comparison with the predictions of the classical theory of linearized elasticity: Part I. Problems with cylindrical symmetry

Acta Mechanica, 2014
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Bustamante Plaza, Roger, Rajagopal, K. R.   +1 more
openaire   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Stress singularity removal and size effect analysis of symmetrical laminated sandwich plates with gradient elasticity theory

Journal of Engineering and Applied Science
This study presents a static analysis of symmetrical laminated sandwich plates using gradient elasticity theory, focusing on the removal of stress singularities in both the face sheets and core layers, and on the size-dependent response evaluated in the ...
Ülkü H. Çalık-Karaköse, Aziz Mert Yavuz   +1 more
doaj   +1 more source

Coupling Approaches with Non-matching Grids for Classical Linear Elasticity and Bond-based Peridynamic Models in 1D

Journal of Peridynamics and Nonlocal Modeling
Local-nonlocal coupling approaches provide a means to combine the computational efficiency of local models and the accuracy of nonlocal models. To facilitate the coupling of the two models, non-matching grids are often desirable as nonlocal grids usually require a finer resolution than local grids.
Patrick Diehl, Emily Downing, Autumn Edwards, Serge Prudhomme   +3 more
openaire   +3 more sources