Results 71 to 80 of about 1,144,514 (290)

IR finite graviton propagators in de Sitter spacetime

, 2016
Graviton propagator diverges in certain gauges in de Sitter spacetime. We address this problem in this work by generalizing the infinitesimal BRST transformations in de Sitter spacetime to finite field-dependent BRST (FFBRST) transformations.
Faizal, Mir, Mandal, Bhabani Prasad, Upadhyay, Sudhaker   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Properties on measure pseudo almost automorphic functions and applications to fractional differential equations in Banach spaces

Electronic Journal of Differential Equations, 2018
In this article, we establish some new composition theorems on measure pseudo almost automorphic functions via measure theory. The obtained compositions theorems generalize those established under the well-known Lipschitz conditions or the classical ...
Yong-Kui Chang, Tian-Wei Feng
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The information metric on the moduli space of instantons with global symmetries

Physics Letters B, 2016
In this note we revisit Hitchin's prescription [1] of the Fisher metric as a natural measure on the moduli space of instantons that encodes the space–time symmetries of a classical field theory. Motivated by the idea of the moduli space of supersymmetric
Emanuel Malek, Jeff Murugan, Jonathan P. Shock   +2 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Modeling and Fusing the Uncertainty of FMEA Experts Using an Entropy-Like Measure with an Application in Fault Evaluation of Aircraft Turbine Rotor Blades

Entropy, 2018
As a typical tool of risk analysis in practical engineering, failure mode and effects analysis (FMEA) theory is a well known method for risk prediction and prevention.
Xuelian Zhou, Yongchuan Tang
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Test of Practice–An Essay

Education Sciences, 2017
This essay starts in medias res, in the puzzling reappearance of the classical metaphor of Bildung as the transformation of man’s “first” animal nature into the “second” cultivated one. I call it the two-natures metaphor.
Lars Løvlie
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source