Results 81 to 90 of about 1,142,466 (290)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Quantum systems as classical systems
, 2001 A characteristical property of a classical physical theory is that the observables are real functions taking an exact outcome on every (pure) state; in a quantum theory, at the contrary, a given observable on a given state can take several values with ...
Antonio Cassa, Jauch J. M.
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Lévy laplacians and annihilation process
Учёные записки Казанского университета: Серия Физико-математические науки, 2018 The Lévy Laplacians are infinite-dimensional Laplace operators defined as the Cesaro mean of the second-order directional derivatives. In the theory of Sobolev–Schwarz distributions over a Gaussian measure on an infinite-dimensional space (the Hida ...
B.O. Volkov
doaj
Detecting Signatures of Criticality Using Divergence Rate
EntropyOftentimes in a complex system it is observed that as a control parameter is varied, there are certain intervals during which the system undergoes dramatic change.
Tenzin Chan +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
A Classical Density-Functional Theory for Describing Water Interfaces
, 2012 We develop a classical density functional for water which combines the White Bear fundamental-measure theory (FMT) functional for the hard sphere fluid with attractive interactions based on the Statistical Associating Fluid Theory (SAFT-VR).
Alberts B. +6 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
KARŞILAŞTIRMALI OLASILIK: NİTELİKSEL/BAĞINTISAL/SEZGİSEL BİR OLASILIK KAVRAMI
Felsefe Dünyası, 2002 Since probabilistic interpretation of the universe in Quantum physics has take: place of deterministic interpretation of it in the classical Newtonian physics, probability has become a more important concept in science and thereby in philosophy of ...
Zekiye Kutlusoy
doaj
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source