Results 81 to 90 of about 3,343,864 (307)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Physics education for the 21st century, solving analytically unsolvable differential equations
Frontiers in Applied Mathematics and StatisticsFor nearly three centuries, Newton’s paradigm—modeling physical systems with differential equations and analyzing them with analytic calculus—defined classical physics.
William Flannery
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Temporal Direction, Intuitionism and Physics
EntropyIn a recent paper, Nicolas Gisin suggests that by conducting physics with intuitionistic rather than classical mathematics, rich temporality—that is, passage and tense, and specifically the future’s openness—can be incorporated into physics.
Yuval Dolev
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Identical Quantum Particles, Entanglement, and Individuality
Entropy, 2020 Particles in classical physics are distinguishable objects, which can be picked out individually on the basis of their unique physical properties. By contrast, in the philosophy of physics, the standard view is that particles of the same kind (“ ...
Dennis Dieks
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Time in Classical and Relativistic Physics [PDF]
, 2013 This is a short, nontechnical introduction to features of time in classical and relativistic physics and their representation in the four-dimensional geometry of spacetime.
Belot, Gordon, Gordon Belot
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
When champions meet: Rethinking the Bohr--Einstein debate [PDF]
, 2005 Einstein's philosophy of physics (as clarified by Fine, Howard, and Held) was predicated on his Trennungsprinzip, a combination of separability and locality, without which he believed objectification, and thereby "physical thought" and "physical laws ...
Landsman, Nicolaas P. +3 more
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source