Results 241 to 250 of about 147,800 (333)

Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer

Advanced Science, EarlyView.
This study develops TMEclassifier, a machine‐learning tool that classifies cancers into three distinct subtypes—Immune exclusive (IE), immune suppressive (IS), and immune activated (IA)—which exhibit significant heterogeneity and necessitate customized therapeutic strategies.
Dongqiang Zeng, Yunfang Yu, Wenjun Qiu, Qiyun Ou, Qianqian Mao, Luyang Jiang, Jianhua Wu, Jiani Wu, Huiyan Luo, Peng Luo, Wenchao Gu, Na Huang, Siting Zheng, Shaowei Li, Yonghong Lai, Xiatong Huang, Yiran Fang, Qiongzhi Zhao, Rui Zhou, Huiying Sun, Wei Zhang, Jianping Bin, Yulin Liao, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Min Shi, Wangjun Liao   +27 more
wiley   +1 more source

Thermodynamics-like Formalism for Immiscible and Incompressible Two-Phase Flow in Porous Media. [PDF]

Entropy (Basel)
Hansen A, Sinha S.
europepmc   +1 more source

Interference Pattern Caused by Bilateral Bone Conduction Stimulation Impairs Sound Localization

Advanced Science, EarlyView.
This work explores how crosstalk‐induced wave interference affects bone conduction (BC) sound localization. Using a theoretical model, cadaveric vibrometry, and psychoacoustic tests, atypical BC lateralization patterns are revealed that contradict air conduction (AC) principles.
Liu‐Jie Ren, Yi Yu, Cheng Hua, You‐Zhou Xie, Wen‐Juan Yao, Jun‐Yi Liang, Chen‐Long Li, Tian‐Yu Zhang   +7 more
wiley   +1 more source

Cognitive Activity of an Individual Under Conditions of Information Influence of Different Modalities: Model and Experimental Research. [PDF]

Entropy (Basel)
Petukhov AY, Morozov NS, Krasnitskiy NV, Petukhov YV.   +3 more
europepmc   +1 more source

In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super‐Resolution Imaging and Genome Modification

Advanced Science, EarlyView.
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge, Joseph B. Wekselblatt, Scott Elmore, Bo Wang, Tongtong Wang, Renjinming Dai, Tingting Zhang, Harsh Dave, Mohammadaref Ghaderi, Athul Raj Anilkumar, Bill Wang, Shashank R. Sirsi, Jung‐Mo Ahn, Mikhail G. Shapiro, Yuki Oka, Carlos Lois, Zhenpeng Qin   +16 more
wiley   +1 more source

What Is Ontic and What Is Epistemic in the Quantum Mechanics of Spin? [PDF]

Entropy (Basel)
Caticha A.
europepmc   +1 more source

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

Advanced Science, EarlyView.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li, Huihui Yu, Ruixian Tian, Xingxing Wang, Ting Xing, Chenyi Xu, Tengteng Li, Xue Du, Qianqian Cui, Biao Yu, Yunxia Cao, Zongzhi Yin   +11 more
wiley   +1 more source

Layer-specific residual strains in human carotid arteries revealed under layer separation. [PDF]

PLoS One
Hrubanová A, Lisický O, Sochor O, Bednařík Z, Joukal M, Burša J.   +5 more
europepmc   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

First-Principles Statistical Mechanics Study of Magnetic Fluctuations and Order-Disorder in the Spinel LiNi_0.5Mn_1.5O₄ Cathode. [PDF]

Chem Mater
García Ponte GE, Behara SS, Bassey EN, Clément RJ, Van der Ven A.   +4 more
europepmc   +1 more source