Results 91 to 100 of about 1,054,693 (288)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Visualising Eclipses: Graphical Constructions of Eclipse Phenomena in the Sanskrit Astral Sciences
HoSTEclipse reckoning constituted a significant component of the Indian astronomical tradition and was underpinned by a sophisticated interplay between mathematical theory, observational data, and visual practices.
Dhammaloka Jambugahapitiye +2 more
doaj +1 more source
Predicting the influence of Circ_0059706 expression on prognosis in patients with acute myeloid leukemia using classical statistics and machine learning. [PDF]
Front Genet, 2022 Ma J +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
From percolation transition to Anderson localization in one-dimensional speckle potentials
New Journal of PhysicsClassical particles in random potentials typically experience a percolation phase transition, being trapped in clusters of mean size χ that diverges algebraically at a percolation threshold.
Margaux Vrech +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Multivariate Analysis under Indeterminacy: An Application to Chemical Content Data
Journal of Analytical Methods in Chemistry, 2020 The Hotelling T-squared statistic has been widely used for the testing of differences in means for the multivariate data. The existing statistic under classical statistics is applied when observations in multivariate data are determined, precise, and ...
Muhammad Aslam, Osama H. Arif
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
The consistency of bootstrap and jackknife variance estimators for finite population L-statistics
Lietuvos Matematikos Rinkinys, 2012 For the linear combinations of order statistics (L-statistics), we present conditions sufficient for the consistency of their finite-population bootstrap variance estimator and the classical jackknife variance estimator.
Andrius Čiginas
doaj +1 more source