Results 121 to 130 of about 14,260,147 (248)

Perspective (Institute for Christian Studies)

, 2015
The laudatio for Dianne Bergsma by James Olthuis appeared in Perspective 48, no. 2 (Sept 2014) http://hdl.handle.net/10756/332755Master of Worldview Studies: To New York and Beyond -- Student Achievements -- Enhancing Global Access to ICS Research ...
Guthrie-McNaughton, Isabella, Hoff, Shannon, Ansell, Nicholas, Institute for Christian Studies, Blomberg, Doug, Sweetman, Robert, Kuipers, Ronald A., Strauss, Gideon, Witvoet, Bert   +8 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Association of Monocyte Subsets with Carotid Artery Stenosis Severity. [PDF]

Medicina (Kaunas)
Deniz L, Sonmez D, Cakir MS, Ozgur E, Akdogan O, Adiyaman Z, Aral H.   +6 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

New Research Programme: Crisis, Conflict and Climate: Societal Change in Scandinavia 300–700 CE

Current Swedish Archaeology
Kerstin Lidén, Gunilla Eriksson, Sven Kalmring, Sven Isaksson, Ludvig Papmehl-Dufay, Helena Viktor   +5 more
doaj   +1 more source

Changing clinical presentation of pediatric celiac disease over time. [PDF]

BMC Gastroenterol
Kalaycik Sengul O, Bal Gumustas P, Celikel K, Arikan AS, Can O, Cam S.   +5 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The Classical-Basal Spectrum in Pancreatic Ductal Adenocarcinoma: A Developmental Framework for Tumour Cell Plasticity and Clinical Translation. [PDF]

Cancers (Basel)
Khan I, Belhaj A, Gemini A, Ibis KA, Darsif N, Rouani N, Vanlander A, Messaoudi N.   +7 more
europepmc   +1 more source