Results 141 to 150 of about 359,341 (361)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Classical Political Philosophy and the Crisis of Modernity – An alternative to the competition State

open access: yesNordicum-Mediterraneum, 2017
The conservative Jewish, German and American philosopher Leo Strauss (1899-1973) proposes an interpretation of the causes of the crisis of modernity and argues that the only way in which we can reestablish social stability is to go back to classical ...
Jacob Dahl Rendtorff
doaj  

On Stalnaker's "Indicative Conditionals" [PDF]

open access: yes
This paper is a guide to the main ideas and innovations in Robert Stalnaker's "Indicative Conditionals". The paper is for a volume of essays on twenty-one classics of formal semantics edited by Louise McNally and Zoltàn Gendler ...
Cariani, Fabrizio
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Pia Guldager and Jane Hjar Petersen (eds.), Meetings of cultures in the Black Sea region. Between conflict and coexistence, (Aarhus: Aarhus University Press, 2008)

open access: yesNordicum-Mediterraneum, 2011
Book review of Pia Guldiger's and Jane H. Petersen's Meeting of cultures in the Black Sea region. Between conflict and coexistence (Aarhus: Aarhus University Press, 2008).
Carlo Cantaluppi
doaj  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

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