Results 41 to 50 of about 544,465 (411)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Menorah Review (No. 60, Winter, 2004) [PDF]

, 2004
America and the Holocaust, Revisited: Notes on the Writing of ... -- The Road to Jewish Nationalism -- From the Classics -- The Reference Shell -- The Fundamentals of Fundamentalism -- From the Classics -- Hasidic Parables, Hasidic Polemics -- From the ...

core   +1 more source

Classical and non-classical models of the cochlea [PDF]

The Journal of the Acoustical Society of America, 1997
In a “classical” model of the cochlea the response is controlled by a local parameter function, for instance, the BM impedance. In a non-classical model, the response is controlled by parameters that are distributed over space. In this note it is shown to which extent classical and non-classical models are equivalent.
openaire   +4 more sources

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Re`class'ification of `quant'ified classical simulated annealing [PDF]

, 2008
We discuss a classical reinterpretation of quantum-mechanics-based analysis of classical Markov chains with detailed balance, that is based on the quantum-classical correspondence. The classical reinterpretation is then used to demonstrate that it successfully reproduces a sufficient condition for cooling schedule in classical simulated annealing ...
arxiv   +1 more source

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

FEBS Letters, EarlyView.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang, Meritxell Wu‐Lu, Alberto Collauto, Peter‐Leon Hagedoorn, Madalina Alexandru, Maike Henschel, Shahram Kordasti, Maria Andrea Mroginski, Maxie M. Roessler, Kourosh H. Ebrahimi   +9 more
wiley   +1 more source

Dickens’ The Cricket on the Hearth: On Its Stylizations, Takeoffs, Adaptations [PDF]

Studia Litterarum
The article considers different imitative approaches to Charles Dickens’ novella “The Cricket on the Hearth” (1845). Our focus is on two groups of adaptations of Dickens’ work: (1) the “plot (non-stylistic) adaptations” and (2) imitations with elements ...
Elena V. Haltrin-Khalturina
doaj   +1 more source

Coins in the Classroom – Teaching Group Work with Roman Coins

The Journal of Classics Teaching, 2020
It can be challenging to bring material culture to life in the classroom when the cultures that produced those materials are separated from the students by time and space.
Gwynaeth McIntyre, Charlotte Dunn, William P. Richardson   +2 more
doaj   +1 more source

Classical communication and non-classical fidelity of quantum teleportation [PDF]

Quantum Inf Process 12, 3607 (2013), 2012
In quantum teleportation, the role of entanglement has been much discussed. It is known that entanglement is necessary for achieving non-classical teleportation fidelity. Here we focus on the amount of classical communication that is necessary to obtain non-classical fidelity in teleportation.
arxiv   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source