Results 121 to 130 of about 115,636 (253)

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

open access: yesAdvanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan   +5 more
wiley   +1 more source

Walkability measures to predict the likelihood of walking in a place: A classification and regression tree analysis. [PDF]

open access: yesHealth Place, 2021
Dalmat RR   +5 more
europepmc   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

open access: yesAdvanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo   +10 more
wiley   +1 more source

International metastatic renal cell carcinoma database consortium classification and regression tree analysis to characterize objective response rates to first line in metastatic renal cell carcinoma. [PDF]

open access: yesFront Oncol
Zarba M   +19 more
europepmc   +1 more source

Optimized Land–Water Management Expands Afforestation Potential Under Land and Human Water‐Use Constraints

open access: yesAdvanced Science, EarlyView.
Human water demand constrains China's feasible afforestation potential more strongly than is commonly recognized, and future climate change further intensifies this limitation. Integrating land‐use optimization with water‐saving measures substantially expands feasible afforestation area and associated carbon sinks, revealing a practical pathway to ...
Binbin Huang   +5 more
wiley   +1 more source

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