Results 151 to 160 of about 115,636 (253)

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Classification and Regression Tree Analysis in Adult Hemophagocytic Syndrome: Identifying Acute Heart Failure Predictors in ICU Patients. [PDF]

J Inflamm Res
Kilincer Bozgul SM, Kurtulmus IA, Yargucu Zihni F, Akad Soyer N, Yagmur B, Gunes A, Koymen G, Bozkurt D.   +7 more
europepmc   +1 more source

Data‐Driven Design of Biofunctional Molecularly Imprinted Polymers for Precision Diagnostics

Advanced Science, EarlyView.
Integrating molecular mechanics/dynamics (MM/MD) with machine learning (ML) enables data‐driven design of nanoMIPs with exceptional performance in multiplex cancer biomarker detection. Guided by the epitopes’ physicochemical and structural traits, ML‐optimized nanoMIPs enhance their charge complementarity, colloidal stability, and binding specificity ...
Nastasia Sanda Moldovean‐Cioroianu, Tamim B. Sarwar, Ekin Sehit, Roland Aydin, Zeynep Altintas   +4 more
wiley   +1 more source

Dissecting Alzheimer's Disease Risk in Asian American Elders: A Classification and Regression Tree Approach. [PDF]

J Alzheimers Dis Rep
Moon SS, Anderson L, Liu J, Lee J, Moon Y.   +4 more
europepmc   +1 more source

Enriched Soil Organic Carbon Underpins Long‐Term Stable Crop Productivity Across China's Croplands

Advanced Science, EarlyView.
Quantifying the nonlinear relationships and causal effects of soil organic carbon (SOC) on crop stability reveals specific critical thresholds and saturation points. This partitions the national SOC spectrum into three functional phases. Integrating these spatial delineations with high‐resolution maps of marginal gains pinpoints regions with the ...
Yuyang Huang, Yulin Shangguan, Zhongkui Luo, Peng Zhu, David Makowski, Zhenzhong Zeng, Qingxu Ma, Min Wei, Yuanyuan Du, Su Ye, Zhou Shi, Songchao Chen   +11 more
wiley   +1 more source

Temporal-Spatial Fluctuations of a Phytoplankton Community and Their Association with Environmental Variables Based on Classification and Regression Tree in a Shallow Temperate Mountain River. [PDF]

Microorganisms
Tian W, Wang Z, Kong H, Tian Y, Huang T.
europepmc   +1 more source

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu, Shu‐Hui Lv, Shui‐Qing He, Yao‐Fei Jiang, Xing‐Si Peng, Jian‐Cong Sun, Fen He, Hai‐Yan Qin, Nian Lu, Wei‐Xin Bei, Lin‐Yu Zhao, Wan‐Qin Shen, Ze‐Yu Zhao, Lin Wang, Yan‐Qun Xiang, Wang‐Zhong Li   +15 more
wiley   +1 more source

Lactate Homeostasis Disruption Potentiates TACE‐Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Lactate homeostasis is disrupted through spatially coordinated extracellular neutralization and intracellular acidification, triggering calcium overload, mitochondrial dysfunction, and immunogenic cell death. This metabolic reprogramming alleviates the immunosuppressive tumor microenvironment and enhances immune checkpoint blockade, providing a ...
Minjiang Chen, Xiaoxiao Chen, Baozhu Yang, Hui Xu, Xueting Sun, Hongkai Qi, Huilin Hu, Ronghua Wu, Fengkai Qiu, Bing Wu, Yu Luo, Gaofeng Shu, Jiansong Ji   +12 more
wiley   +1 more source

Stage‐Adaptive Bilayer Hydrogel Coordinates Photodynamic Antibacterial Therapy with Engineered Extracellular Vesicle–Mediated Immunomodulation in Infected Diabetic Wounds

Advanced Science, EarlyView.
Early photodynamic infection control and subsequent immunoregulatory repair are spatially separated within a stage‐adaptive bilayer hydrogel. Chlorin e6 is incorporated into the wound‐contacting layer to provide light‐triggered bactericidal therapy, whereas the upper layer regulates excessive reactive oxygen species before releasing microRNA‐146a ...
Gaofei Zhang, Boheng Zhu, Shihao Deng, Pan Du, Jun Pu, Xin Wang, Shuqian Dou, Yifei Wang, Wenjun Liu   +8 more
wiley   +1 more source

Predictors of Hyperkalemia and Hypokalemia in Individuals with Diabetes: a Classification and Regression Tree Analysis. [PDF]

J Gen Intern Med, 2020
Schroeder EB, Adams JL, Chonchol M, Nichols GA, O'Connor PJ, Powers JD, Schmittdiel JA, Shetterly SM, Steiner JF.   +8 more
europepmc   +1 more source