Results 91 to 100 of about 3,096,410 (281)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An RL-Enhanced Multi-Agent Framework for Scalable and Intelligent Business Intelligence Systems

Information
In many organizations, business intelligence systems support analytical reporting and operational decision making. As data volumes grow and analytical tasks become more complex, architectures based on centralized processing pipelines increasingly face ...
Khamza Eshankulov, Kudratjon Zohirov, Ilkhom Bakaev, Shafiyev Tursun, Nazarov Shakhzod, Zavqiddin Temirov, Rashid Nasimov   +6 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dynamic Classification: Leveraging Self-Supervised Classification to Enhance Prediction Performance

IEEE Access
In this study, we propose an innovative dynamic classification algorithm aimed at achieving zero missed detections and minimal false positives, critical in safety-critical domains (e.g., medical diagnostics) where undetected cases risk severe outcomes ...
Ziyuan Zhong, Junyang Zhou
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

An Empirical Study of a Simple Incremental Classifier Based on Vector Quantization and Adaptive Resonance Theory

International Journal of Applied Mathematics and Computer Science
When constructing a new data classification algorithm, relevant quality indices such as classification accuracy (ACC) or the area under the receiver operating characteristic curve (AUC) should be investigated. End-users of these algorithms are interested
Czmil Sylwester, Kluska Jacek, Czmil Anna   +2 more
doaj   +1 more source

Change of direction ability performance in cerebral palsy football players according to functional profiles

Frontiers in Physiology, 2016
The aims of the present study were to evaluate the validity and reliability of the two different change of direction ability (CODA) tests in elite football players with cerebral palsy (CP) and to analyse the differences in performance of this ability ...
Raul eReina, Jose eSarabia, Javier eYanci, Maria eGarcía-Vaquero, Maria eCampayo   +4 more
doaj   +1 more source

Performance Measures in Binary Classification

International Journal of Statistics in Medical Research, 2012
We give a brief overview over common performance measures for binary classification. We cover sensitivity, specificity, positive and negative predictive value, positive and negative likelihood ratio as well as ROC curve and AUC.
openaire   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source