Results 111 to 120 of about 122,356 (296)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The hierarchical coarse-graining schema for anatomical aggregation of side effects to address redundancy and to achieve improved, meaningful classification.

, 2018
The hierarchical coarse-graining schema for anatomical aggregation of side effects to address redundancy and to achieve improved, meaningful classification.
Shubham Dokania (4904440), Rakesh Kanji (4904437), Somin Wadhwa (4904443), Ganesh Bagler (119952), Aishwarya Gupta (4904434)   +4 more
core   +1 more source

SNMatch: An Unsupervised Method for Column Semantic-Type Detection Based on Siamese Network

Mathematics
Column semantic-type detection is a crucial task for data integration and schema matching, particularly when dealing with large volumes of unlabeled tabular data.
Tiezheng Nie, Hanyu Mao, Aolin Liu, Xuliang Wang, Derong Shen, Yue Kou   +5 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Classification schema for online communities

, 1998
A synthesis of the literature suggests that the key characteristics for classifying online communities are: (i)their attributes, (ii) supporting software, (iii) their relationship to physical communities, and (iv) the sociological concept of boundedness.
Jennifer Preece, Preece, Jenny, Jonathan Lazar, Lazar, Jonathan   +3 more
core  

A Graph Data Model for CityGML Utility Network ADE: A Case Study on Water Utilities

ISPRS International Journal of Geo-Information
Modelling connectivity in utility networks is essential for operational management, maintenance planning, and resilience analysis. The CityGML Utility Network Application Domain Extension (UNADE) provides a detailed conceptual framework for representing ...
Ensiyeh Javaherian Pour, Behnam Atazadeh, Abbas Rajabifard, Soheil Sabri, David Norris   +4 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

The schema for hierarchical anatomical classification of side effects by aggregating them into their associated organs, sub-systems and systems.

, 2018
The schema for hierarchical anatomical classification of side effects by aggregating them into their associated organs, sub-systems and systems.
Shubham Dokania (4904440), Rakesh Kanji (4904437), Somin Wadhwa (4904443), Ganesh Bagler (119952), Aishwarya Gupta (4904434)   +4 more
core   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source