Results 41 to 50 of about 122,356 (296)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Automatic schema classification for Schema-Focused Therapy using k-Nearest Neighbour

, 2021
Personality disorders affect 1 in 7 adults reducing their quality of life. Schema-focused therapy (SFT) has become very popular in Psychotherapy in the treatment of personality disorders (PD), unfortunately there is still in increasing societal need for ...
Han, Budi (author)
core  

The core genome multi-locus sequence typing of Mycoplasma anserisalpingitidis

BMC Genomics, 2020
Background Mycoplasma anserisalpingitidis is a waterfowl pathogen that mainly infects geese, can cause significant economic losses and is present worldwide.
Áron B. Kovács, Zsuzsa Kreizinger, Barbara Forró, Dénes Grózner, Alexa Mitter, Szilvia Marton, Krisztina Bali, Anna Sawicka, Grzegorz Tomczyk, Krisztián Bányai, Miklós Gyuranecz   +10 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

An APOS analysis of natural science students’ understanding of integration

REDIMAT, 2014
This article reports on a study which used the APOS (action-process-object-schema) Theory framework and a classification of errors toinvestigate university students’ understanding of the integration concept and its applications.
Aneshkumar Maharaj
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Schema Theory-based Computational Approach to Support Children's Conceptual Understanding [PDF]

, 2006
Researchers acknowledge the difficulty faced by children in understanding new concepts. Explaining new concepts to children requires supporting their reasoning based on concrete objects and ideas.
Ibrahim, Zukeri
core  

Burhan: A Constraint-Based Engineering Framework for Computational Rhetorical Semantics in Classical Arabic

IEEE Access
Figurative language poses persistent challenges for Natural Language Processing (NLP), as distributional representations struggle to model non-compositional semantic mappings.
Reema G. Al-Anazi, Wadee A. Nashir, Badriyya B. Al-Onazi, Anoud A. Alhamad, Hassan Alshamrani, Wala F. Bin Subait   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source