Results 81 to 90 of about 2,032,765 (290)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Schema of the classification.

, 2013
Schema of the classification.
Olga Kirillova (319518)
core   +1 more source

The Scholix Metadata JSON Schema

, 2022
This product consists of the XML schema and the JSON schema aligned with the Scholix Metadata Guidelines Version 4. It contains the .json and /xsd files together with examples of compatible metadata records.
Sandro La Bruzzo, Paolo Manghi
core   +1 more source

Comparison of Supervised-learning Models for Infant Cry Classification / Vergleich von Klassifikationsmodellen zur Säuglingsschreianalyse

International Journal of Health Professions, 2015
Cries of infants can be seen as an indicator for several developmental diseases. Different types of classification algorithms have been used in the past to classify infant cries of healthy infants and those with developmental diseases.
Fuhr Tanja, Reetz Henning, Wegener Carla
doaj   +1 more source

J.-M. Le Clézio : une poétique aux frontières des genres

Mosaïque, 2010
Malgré la classification des genres et les caractéristiques qui leur sont dévolues, de nombreux écrivains militent en faveur d’une écriture qui ne peut prospérer que dans un environnement débarrassé de toutes formes de conformisme. L’œuvre de Le
Mike Kouakou
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

bowtie-json-schema/bowtie: v0.74.1

, 2023
What's Changed Bump serde from 1.0.154 to 1.0.155 in /implementations/rust-jsonschema by @dependabot in https://github.com/bowtie-json-schema/bowtie/pull/168 Bump serde from 1.0.155 to 1.0.156 in /implementations/rust-jsonschema by @dependabot in https:/
Julian Berman, Greg Dennis, Akanksha Kushwaha, Jason Desrosiers, Santhosh Kumar Tekuri   +4 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source