Results 21 to 30 of about 253 (115)
Systems Engineering, EarlyView.ABSTRACT System of Systems (SoS) environments are inherently complex, involving numerous operationally and managerially independent component systems with hidden interdependencies and frequent interactions based on unstructured data. In this paper, we propose using graphical Retrieval‐Augmented Generation (GraphRAG), a tool that combines large language
Yinchien Huang +2 more
wiley +1 more source
Identification of Missing Knowledge in MBSE System Models Using Graph‐Based Machine Learning
Systems Engineering, EarlyView.ABSTRACT The design and development of complex aerospace systems pose significant challenges due to their growing complexity. Iterative design processes, guided by formal specifications, strive to refine initially vague characteristics through multiple stages.
Esma Karagoz +2 more
wiley +1 more source
Can unsupervised machine learning gain new insights into urodynamic pressure flow pattern analysis?
BJU International, EarlyView.Objectives To explore the use of unsupervised machine learning (UML) to analyse segments of the pressure flow study (PFS) curve after maximum flow, and subsequently to analyse the urodynamic and patient characteristics of men in the detected clusters. Subjects and Methods In this study, we considered 1650 PFSs of men with lower urinary tract symptoms ...
Wouter van Dort +4 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez +13 more
wiley +1 more source
The FEBS Journal, EarlyView.Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk +8 more
wiley +1 more source
TGFβ enhances platelet–breast‐cancer‐cell interaction and promotes platelet aggregation
The FEBS Journal, EarlyView.TGFβ stimulation promotes EMT in MCF7 cells, increasing their ability to bind, activate, and aggregate PLT. This effect involves the upregulation of adhesion molecules Integrin‐αv and Galectin‐3. Inhibiting Integrin‐αv or Galectin‐3, through Cilengitide and GB1103, reduces PLT adhesion to MCF7 and PLT aggregation, suggesting a mechanism linking TGFβ ...
Margherita Genitoni +7 more
wiley +1 more source
Dietary anthocyanidin pelargonidin activates G protein‐coupled receptor 35
The FEBS Journal, EarlyView.Pelargonidin, a red‐fruit‐derived anthocyanidin, was newly identified as a dietary agonist of GPR35, a metabolite‐sensing GPCR implicated in anti‐inflammation. Through screening of dietary compounds, pelargonidin emerged as a potent GPR35 agonist, attenuating inflammation in human intestinal cells.
Fumie Nakashima +11 more
wiley +1 more source
The FEBS Journal, EarlyView.CellMorph is a groundbreaking tool that allows researchers to analyze multiple features from single cells, including cell size and shape, cytosolic staining and subcellular texture, nuclear staining, and morphometry. By evaluating images from both bright‐field and fluorescence microscopy, it also tracks changes in living cells during key processes such
Henrique Quaiato de Oliveira +16 more
wiley +1 more source
Districting in last‐mile delivery with stochastic customers
International Transactions in Operational Research, EarlyView.Abstract Due to the peculiarities of city streets, last‐mile logistics is typically organized using territory‐based routing approaches, which divide the city into a set of districts and assign drivers to deliver in one or more of them. This allows drivers to develop a deep understanding of the characteristics of each district, and clients benefit from ...
Maria Elena Bruni +3 more
wiley +1 more source
Journal of Gastroenterology and Hepatology, EarlyView.ABSTRACT Background The efficacy of neoadjuvant chemotherapy (NAC) combined with surgery and postoperative adjuvant chemotherapy in improving the prognosis of locally advanced gastric cancer (LAGC) has been confirmed. Nevertheless, there is still no effective tool to predict the response to NAC in gastric cancer patients.
Minxuan Shen +11 more
wiley +1 more source