Results 21 to 30 of about 1,065,063 (179)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
An implementation of the behavior annex in the AADL-toolset Osate2 [PDF]
, 2011 AADL is a modeling language to design and analyze High-Integrity Distributed and Real-time systems. Embedded sub-languages published as AADL annexes extend an AADL model to enhance analysis.
Hugues, Jérôme +3 more
core +2 more sources
Automatic Classification of Web Images as UML Static Diagrams Using Machine Learning Techniques
Applied Sciences, 2020 Our purpose in this research is to develop a method to automatically and efficiently classify web images as Unified Modeling Language (UML) static diagrams, and to produce a computer tool that implements this function. The tool receives a bitmap file (in
Valentín Moreno +3 more
semanticscholar +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
UML Deficiencies from the perspective of Automatic Performance Model Generation [PDF]
, 1999 A discussion surrounding the use of UML for distributed system ...
Akehurst, David H., Waters, A. Gill
core
Refactoring OCL annotated UML class diagrams [PDF]
, 2005 Refactoring of UML class diagrams is an emerging research topic and heavily inspired by refactoring of program code written in object-oriented implementation languages. Current class diagram refactoring techniques concentrate on the diagrammatic part but
Baar, Thomas, Marković, Slaviša
core +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Building an evaluation instrument for OO CASE tool assessment for Unified Modelling Language support [PDF]
, 1999 The Unified Modelling Language (UML) as delivered in September 1997 offers the structure and dynamics of its modelling constructs developed in order to standardise different object oriented (OO) development practices.
Juric, R. +3 more
core +1 more source
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source