Results 41 to 50 of about 134,366 (254)

CD46 Gene Editing Confers Ex Vivo BVDV Resistance in Fibroblasts from Cloned Angus Calves

Viruses
A previous study demonstrated that a 19-nucleotide edit, encoding a six amino acid substitution in the bovine CD46 gene, dramatically reduced bovine viral diarrhea virus (BVDV) susceptibility in a cloned Gir (Bos indicus) heifer.
Aspen M. Workman, Michael P. Heaton, Brian L. Vander Ley   +2 more
doaj   +1 more source

Data‐Driven Bulldozer Blade Control for Autonomous Terrain Leveling

Advanced Robotics Research, EarlyView.
A simulation‐driven framework for autonomous bulldozer leveling is presented, combining high‐fidelity terramechanics simulation with a neural‐network‐based reduced‐order model. Gradient‐based optimization enables efficient, low‐level blade control that balances leveling quality and operation time.
Harry Zhang, Ganesh Arivoli, Huzaifa Unjhawala, Luning Bakke, Radu Serban, Dan Negrut   +5 more
wiley   +1 more source

Genes Associated With Chromatin Modification Within the Swine Placenta Are Differentially Expressed Due to Factors Associated With Season

Frontiers in Genetics, 2020
Seasonal reproductive inefficiency is still observed in modern swine facilities. We previously reported global placental methylation activity was reduced from summer breedings and tended to be less from semen collected during cooler periods.
Lea A. Rempel, John J. Parrish, Jeremy R. Miles   +2 more
doaj   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Tolerance to Morphine-Induced Inhibition of TTX-R Sodium Channels in Dorsal Root Ganglia Neurons Is Modulated by Gut-Derived Mediators

iScience, 2018
Summary: In the clinical setting, analgesic tolerance is a primary driver of diminished pain control and opioid dose escalations. Integral to this process are primary afferent sensory neurons, the first-order components of nociceptive sensation. Here, we
Ryan A. Mischel, William L. Dewey, Hamid I. Akbarali   +2 more
doaj   +1 more source

Highly Efficient and Environmentally Stable Radiative Cooling Fabric: Integrating Photoluminescence and Hierarchical Core–Shell Fibers

Advanced Science, EarlyView.
A scalable radiative cooling fabric engineered with a multi‐layer assembly core–shell structure and integrated photoluminescent materials is reported. The fabric exhibits remarkable environmental stability, including UV resistance, mechanical durability, hydrophobicity, stain resistance, thermal stability, and flame retardancy, demonstrating its ...
Hongtao Liu, Hui Li, Yining Wang, Wei Sun, Zhuan Chen, Yongping Hou, Yongmei Zheng, Xuejian Chen, Bin Yu   +8 more
wiley   +1 more source

Using diverse U.S. beef cattle genomes to identify missense mutations in EPAS1, a gene associated with pulmonary hypertension [version 2; referees: 2 approved]

F1000Research, 2016
The availability of whole genome sequence (WGS) data has made it possible to discover protein variants in silico. However, existing bovine WGS databases do not show data in a form conducive to protein variant analysis, and tend to under represent the ...
Michael P. Heaton, Timothy P.L. Smith, Jacky K. Carnahan, Veronica Basnayake, Jiansheng Qiu, Barry Simpson, Theodore S. Kalbfleisch   +6 more
doaj   +1 more source

The Third‐Generation Magnetic Super‐Stable Mineralizer: Complete Removal and Separation of Multiple Heavy Metal Pollutants

Advanced Science, EarlyView.
The 3rd‐generation magnetic super‐stable mineralizer M‐MgAl‐700 features a core‐shell structure, strong superparamagnetism, large surface area, and abundant oxygen defects. It achieves exceptional Cd(II) and As(V) mineralization capacities, reducing both pollutants in co‐contaminated water and soil to meet national standards.
Haoran Wang, Menghan Huang, Ruihua Mao, Xiaohan Zhang, Zhaohui Wu, Xiaofeng Pang, Tong Lin, Dongyuan Cui, Sai An, Yu‐Fei Song   +9 more
wiley   +1 more source

A New Customizable Surfactant LLPS Strategy for Sustainable and Highly Efficient Radioactive Metal Ion Separation

Advanced Science, EarlyView.
A diluent‐free, customizable liquid–liquid phase separation (LLPS) platform enables highly efficient radioactive metal ion extraction and stripping. By encapsulating hydrophobic extractants into an ionic surfactant‐rich condensed phase, this LLPS system leverages synergistic electrostatic and coordination interactions.
Ruihan Yan, Yifu Hu, Wentao Wang, Zhi Cao, Meiwen Cao, Weifang Zheng, Guoan Ye, Taihong Yan   +7 more
wiley   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source