Results 41 to 50 of about 103,175 (263)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Development of a Self-Cleaning Mechanism for Torque-Flow Pumps

Журнал інженерних наук
The design of reliable and durable pumping units is consistent with the achievement of a number of the United Nations’ sustainable development goals (SDG), in particular, “Clean water and proper sanitation” (SDG 6), “Affordable and clean energy” (SDG 7),
Vladyslav Kondus, Olaf Ciszak, Andriy Zhukov, Maksym Mushtai, Vadym Polkovnychenko, Andrii Krugliak   +5 more
doaj   +1 more source

High-Efficiency Automatic Recharging Mechanism for Cleaning Robot Using Multi-Sensor

Sensors, 2018
Cleaning robot has the highest penetration rate among the service robots. This paper proposes a high-efficiency mechanism for an intelligent cleaning robot automatically returns to charging in a short time when the power is insufficient.
Ching-Lung Chang, Chuan-Yu Chang, Zhi-Yuan Tang, Shuo-Tsung Chen   +3 more
doaj   +1 more source

Screen cleaner for on farm processing of grains

The Indian Journal of Agricultural Sciences, 2021
Cleaning is the first unit operation performed on threshed grain to remove field impurities. Presently, cleaning machines are operated using conventional energy sources which are either uncertain or non-affordable to farmers.
PRAMOD P ARADWAD, ARUN KUMAR T V, J P SINHA, RAHUL S YADAV   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Study of Patterns and Mechanisms of Continuous Laser Ablation of Carbon Steel Rust Layers in Multi-Medium Environments

Applied Sciences
A new multi-scenario, low-cost, high-efficiency, medium-assisted continuous laser cleaning of corrosion layers was developed. By comparing the roughness and cleaning depth of rust layers cleaned under conditions of liquid-assisted, solid-assisted, and ...
Kunyu Cui, Jian Luo, Kefeng Xu, Lei Ling, Riping Cheng   +4 more
doaj   +1 more source

Study on pickling technology to control fouling of ceramic membrane treating secondary treated effluent

Water Science and Technology, 2022
The application of membrane technology in the field of water treatment was increasingly widespread, but membrane fouling still restricted its development, and the membrane needed to be chemically cleaned.
Fengchao Wang, Shoubin Zhang, Wenhai Jiao, Jingying Chen, Shikai Zhao, Guoqiang Ma, Guicai Liu   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Design and simulation analysis of automatic coal spillage cleaning mechanism for belt conveyors in underground roadways

Gong-kuang zidonghua
As the main coal flow transportation equipment in underground coal mines, belt conveyors may experience coal spillage and accumulation during operation. Traditional manual cleaning methods are inefficient and pose safety hazards.
YANG Jiao, LI Chong, BAO Jiusheng, YANG Rui, ZHANG Xiaoniu, WANG Lei, HU Eryi, DAI Shouchen   +7 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source