Results 61 to 70 of about 573,791 (286)

ACE2 in tumor cells and tumor vasculature: Negligible intercellular transfer from cancer cells into endothelial cells

open access: yesVisualized Cancer Medicine, 2021
Cancer patients are more susceptible to severe coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Angiotensin-converting enzyme 2 (ACE2) is the functional host receptor for SARS-
Liu Zhi-Jie   +12 more
doaj   +1 more source

Valdez-Jimenez v. Eighth Jud. Dist. Ct.,136 Nev. Adv. Op. 20 (April 9, 2020)

open access: yes, 2020
The Court determined what process is constitutionally required when a district court sets bail in an amount that the defendant cannot afford, resulting in pretrial detention.
Weil, Katrina
core  

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang   +7 more
wiley   +1 more source

The Parental Rights of Rapists [PDF]

open access: yes, 2012
We consider the joint allocation of receiver, bit, and power to subcarriers in the downlink of multicell orthogonal frequency-division multiple-access (OFDMA) networks.
Bitar, Kara N.
core   +3 more sources

Disk-Driven Rotating Bipolar Outflow in Orion Source I

open access: yes, 2017
One of the outstanding problems in star-formation theory concerns the transfer of angular momentum such that mass can accrete onto a newly born young stellar object (YSO).
Burns, Ross A.   +7 more
core   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider   +20 more
wiley   +1 more source

Autoregressive transitional ordinal model to test for treatment effect in neurological trials with complex endpoints

open access: yesBMC Medical Research Methodology, 2016
Background A number of potential therapeutic approaches for neurological disorders have failed to provide convincing evidence of efficacy, prompting pharmaceutical and health companies to discontinue their involvement in drug development.
Lorenzo G. Tanadini   +3 more
doaj   +1 more source

The Federal Sentencing Guidelines: Adopting Clear and Convincing Evidence as the Burden of Proof

open access: yesThe University of Chicago Law Review, 1990
In 1984 Congress passed the Sentencing Reform Act (the "Act")1 in response to the widely held view that defendants who committed similar crimes, under similar circumstances, were receiving grossly disproportionate sentences in federal courts.2 The Act established the Federal Sentencing Commission (the "Commission") to promulgate mandatory sentencing ...
openaire   +2 more sources

Stress‐Induced Melting Controlled Failure Mechanisms of Methane Hydrate

open access: yesAdvanced Science, EarlyView.
We study methane hydrate via nanoindentation and nuclear magnetic resonance (NMR), finding its regional melting and mechanical properties, challenging existing views on hydrogen‐bonded crystals. Abstract Methane hydrate, a kind of nonstoichiometric crystalline, attracted worldwide attentions as a promising substitute energy. Its Dissociation is thought
Yanlong Li   +9 more
wiley   +1 more source

Not without justification [PDF]

open access: yes, 2011
In this paper I take issue with Jonathan Sutton's attempt at defending the thesis that knowledge is justified belief. I argue, first, that the arguments he adduces in support of it fail.
Kelp, Christoph
core   +1 more source

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