Results 191 to 200 of about 337,050 (372)

The von Hippel-Lindau Tumor Suppressor Protein and Clear Cell Renal Carcinoma [PDF]

, 2007
William G. Kaelin
openalex   +1 more source

piR‐RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX‐1 Cytoplasm Localization

Advanced Science, EarlyView.
PIWI‐interacting RNAs (piRNAs), a novel category of small non‐coding RNAs, have been implicated in the development of various diseases. This study explores the tumor‐suppressive mechanism of a downregulated piRNA (designated piR‐RCC) in renal cell carcinoma (RCC), and provides a delivery strategy targeting RCC tumor by constructing a cell membrane ...
Ruyue Wang, Fan Li, Yudong Lin, Zeyi Lu, Wenqin Luo, Zhehao Xu, Ziwei Zhu, Yi Lu, Xudong Mao, Yang Li, Zhinian Shen, Haohua Lu, Yining Chen, Liqun Xia, Mingchao Wang, Lifeng Ding, Gonghui Li   +16 more
wiley   +1 more source

A Phase I Dose-Escalation Study of the HIF-2 Alpha Inhibitor DFF332 in Patients with Advanced Clear-Cell Renal Cell Carcinoma [PDF]

Dose-escalation; Inhibitor; Clear-cell renal cell carcinomaEscalada de dosis; Inhibidor; Carcinoma renal de células clarasEscalada de dosi; Inhibidor; Carcinoma renal de cèl·lules claresPurpose: Mutations or silencing of the von Hippel–Lindau tumor ...
Bernard-Tessier, Alice, Gao, Xin, Grell, Peter, Kotecha, Ritesh, Pal, Sumanta, Picus, Joel, Suárez, Cristina   +6 more
core   +1 more source

Clinical factors associated with outcome in patients with metastatic clear‐cell renal cell carcinoma treated with vascular endothelial growth factor‐targeted therapy [PDF]

, 2007
Toni K. Choueiri, Jorge A. García, Paul Elson, Mohamad Khasawneh, Saif Usman, Ali Golshayan, Rachid Baz, Laura S. Wood, Brian I. Rini, Ronald M. Bukowski   +9 more
openalex   +1 more source

Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma

Nature Network Boston, 2020
D. Braun, Yue Hou, Z. Bakouny, M. Ficial, Miriam Sant’ Angelo, J. Forman, P. Ross-Macdonald, Ashton C. Berger, O. Jegede, L. Elagina, J. Steinharter, Maxine Sun, M. Wind-Rotolo, Jean-Christophe Pignon, A. Cherniack, Lee T Lichtenstein, D. Neuberg, P. Catalano, G. Freeman, A. Sharpe, D. McDermott, E. V. Van Allen, S. Signoretti, Catherine J. Wu, S. Shukla, T. Choueiri   +25 more
semanticscholar   +1 more source

Granulomas in clear cell renal cell carcinomas [PDF]

Journal of Current Pathology, 2017
PAKSOY, SERPİL, BEHZATOĞLU, KEMAL, ŞEN, SAİT, YÖRÜKOĞLU, KUTSAL, TUNA, EMİNE BURÇİN, KARAARSLAN, SERAP, SARSIK KUMBARACI, BANU, OKÇU, OĞUZHAN   +7 more
openaire   +3 more sources

Phosphorylation‐Dependent Stabilization of Collaborator of ARF (CARF) Suppresses Lymphoma Cell Proliferation

Advanced Science, EarlyView.
This study revealed that oncogene Collaborator of ARF (CARF) is closely related to B‐cell lymphoma tumorigenesis, and shares a conserved mechanism regulating protein stability with Arabidopsis Kip‐Related Protein6 (KRP6) through casein kinase 1‐mediated phosphorylation. Reduced phosphorylation led to the enhanced protein stability of CARF, resulting in
Li Qu, Zhuang Wei, Shuting Zhou, Xiaofan Zhang, Wenjun Zhang, Aibin Liang, Zhe Wang, Hongwei Xue   +7 more
wiley   +1 more source

High-grade clear cell renal cell carcinoma has a higher angiogenic activity than low-grade renal cell carcinoma based on histomorphological quantification and qRT–PCR mRNA expression profile [PDF]

, 2007
Marcella Baldewijns, Victor L. Thijssen, Gert G. Van den Eynden, Steven Van Laere, Adriana M. J. Bluekens, Tania Roskams, Hendrik Van Poppel, Adriaan P. de Bruı̈ne, Arjan W. Griffioen, P Vermeulen   +9 more
openalex   +1 more source

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng   +11 more
wiley   +1 more source

EOSINOPHILIC VARIANT OF CLEAR CELL RENAL CELL CARCINOMA - A DIAGNOSTIC DILEMMA [PDF]

, 2019
Introduction: Eosinophilic variant of clear cell renal cell carcinoma is an important entity to diagnose since it is aggressive and is associated with poor prognosis. Case Report: A 75-year-old patient presented with pain abdomen.
K, SUMAN, MONAPPA, VIDYA, RAO, NAMRATA
core   +1 more source