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Cell heterogeneity in clear cell renal cell carcinoma
APMIS, 2013The aim of this study was to define the histological spectrum, frequency and significance of nonconventional tumour cells in clear cell renal cell carcinomas (CCRCC). Fifty‐one totally sampled CCRCC were studied histologically to evaluate the spectrum of cell morphology variability, its frequency and significance, and their correlation with tumour ...
José I, Lopez +4 more
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Therapeutic approaches in clear cell and non-clear cell renal cell carcinoma
Acta Clinica Belgica, 2016Renal cell carcinoma (RCC) accounts for 2.4% of all malignancies worldwide diagnosed with 338,000 estimated new cases globally in 2012. In the last decade, the therapeutic landscape for RCC patients has changed tremendously. In this review, we will summarize the treatment options currently available for clear-cell localized, advanced and metastatic RCC
T, Vermassen +3 more
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American Journal of Surgical Pathology, 2015
Clear cell papillary renal cell carcinoma is increasingly recognized as a distinct tumor with unique morphology, immunohistochemistry, and cytogenetics. Histopathology often mimics clear cell renal cell carcinoma; however, metastasis has not been reported, emphasizing the clinical value of recognizing these likely nonaggressive tumors.
Sean R, Williamson +8 more
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Clear cell papillary renal cell carcinoma is increasingly recognized as a distinct tumor with unique morphology, immunohistochemistry, and cytogenetics. Histopathology often mimics clear cell renal cell carcinoma; however, metastasis has not been reported, emphasizing the clinical value of recognizing these likely nonaggressive tumors.
Sean R, Williamson +8 more
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Chemotherapy for Non–Clear-Cell Renal Cell Carcinoma
Clinical Genitourinary Cancer, 2006Clear-cell carcinoma is the most common histopathologic subtype of kidney tumors. Consequently, clinical trials for advanced-stage kidney cancer have focused on patients with clear-cell carcinoma and not on the less common subtypes, including papillary, chromophobe, collecting-duct carcinoma, and sarcomatoid-variant tumors.
Kevin A, David +2 more
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T2 CLEAR CELL RENAL CELL CARCINOMA IS A RARE ENTITY: A STUDY OF 120 CLEAR CELL RENAL CELL CARCINOMAS
Journal of Urology, 2005In 2002 the American Joint Committee on Cancer revised the TNM staging system, introducing subclassification for T1 tumors, and invasion of renal sinus fat and sinus veins in categories T3a and T3b, respectively. Since renal sinus invasion represents the most common site of extrarenal extension, the relationship between size, and renal sinus invasion ...
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Progression of Malignancy in Clear Cell Renal Cell Carcinomas
Scandinavian Journal of Surgery, 2004Much progress has recently been obtained in the classification and characterization of RCC by using cytogenetic, gene microarray and proteomic techniques. Pivotal for the understanding of the progression of malignancy of clear cell renal cell carcinomas are findings connecting its biology to inactivation of the von Hippel-Lindau tumour suppressor gene ...
I, Virtanen, V P, Lehto
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Proteomic signatures of clear cell renal cell carcinoma
Nature Reviews Nephrology, 2019In recent years, the molecular view of clear cell renal cell carcinoma (ccRCC) has been based primarily on gene transcription data with limited information on protein features. A new study led by the Clinical Proteomic Tumor Analysis Consortium now offers a comprehensive view of the ccRCC proteome.
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