Results 71 to 80 of about 337,050 (372)

The Metastasis Pattern of Renal Cell Carcinoma Is Influenced by Histologic Subtype, Grade, and Sarcomatoid Differentiation

Medicina, 2023
Background and Objectives: Metastasis is a major cause of death in renal cell carcinoma (RCC) patients; therefore, a better understanding of the metastatic process and the ability to predict metastasis in advance is important for treating patients with ...
Hyung Kyu Park
doaj   +1 more source

A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma

Nature Communications, 2022
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer in adults. When ccRCC is localized to the kidney, surgical resection or ablation of the tumor is often curative.
A. Alchahin, S. Mei, Ioanna Tsea, Taghreed Hirz, Y. Kfoury, D. Dahl, Chin-Lee Wu, Alexander O. Subtelny, Shulin Wu, D. Scadden, John H. Shin, P. Saylor, D. Sykes, P. V. Kharchenko, Ninib Baryawno   +14 more
semanticscholar   +1 more source

Prognostic relevance of the histological subtype of renal cell carcinoma [PDF]

, 2008
OBJECTIVE: According to several studies, when the histological subtype of renal cell carcinoma is established it is possible to attribute a different life expectancy to each patient.
ANTUNES, Alberto A., DALL'OGLIO, Marcos F., LEITE, Katia R. M., MOSCONI, Alcides, POMPEO, Antonio C., Srougi, Miguel   +5 more
core   +2 more sources

Immunotherapy of Clear-Cell Renal-Cell Carcinoma

Cancers
Clear-cell Renal-Cell Carcinoma (ccRCC) is the most common type of renal-cell carcinoma (RCC). In many cases, RCC patients manifest the first symptoms during the advanced stage of the disease. For this reason, immunotherapy appears to be one of the dominant treatments to achieve a resolution.
Sophie Grigolo, Luis Filgueira
openaire   +2 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Clear Cell Papillary Renal Cell Carcinoma: A Potential Mimic of Conventional Clear Cell Renal Carcinoma on Core Biopsy

Case Reports in Urology, 2015
Clear cell papillary renal cell carcinoma (CCP-RCC) is a recently described, relatively uncommon variant of renal cell carcinoma (RCC) with a reported incidence of 4.1%. Thought to only arise in those with end stage renal disease, CCP-RCC is increasingly
Heath Liddell, Anton Mare, Sean Heywood, Genevieve Bennett, Hin Fan Chan   +4 more
doaj   +1 more source

Leveraging diverse cell-death related signature predicts the prognosis and immunotherapy response in renal clear cell carcinoma

Frontiers in Immunology, 2023
BackgroundModulation of programmed cell death in tumor cells alters the tumor microenvironment and the influx of tumor-infiltrating lymphocytes, and the combination of its inducers and immune checkpoint inhibitors plays a synergistic role in enhancing ...
Zhengqi Wu, Mingyue Jin, Peng Xin, Hao Zhang   +3 more
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Multilocular Cystic Renal Cell Carcinoma: An Unusual Gross Appearance [PDF]

, 2011
Multilocular Cystic Renal Cell Carcinoma (MCRCC) represents a rare variant of clear cell (conventional) renal cell carcinomas. Attributable to its distinct characteristics in prognosis and its natural history, MCRCC was recognised as a separate subtype ...
Jagtap, SV, Jain, G, Mali, RK, Nikumbh, DB   +3 more
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source