Results 101 to 110 of about 4,051,168 (295)

Activity‐Selectivity Trends in Electrochemical Urea Synthesis: Co‐Reduction of CO2 and Nitrates Over Single‐Site Catalysts

Advanced Science
Electrochemical co‐reduction of carbon dioxide and nitrates (CO2NO3RR) holds promise for sustainable urea production. However, the sluggish kinetics of the sixteen‐electron transfer and unclear mechanistic understanding strongly impede its development ...
Qinglan Zhao, Yushen Liu, Yuan Zhang, Shangqian Zhu, Hongming Xu, Mohammad Farhadpour, Fei Xiao, Minghui Xing, Dapeng Cao, Xueping Qin, Tejs Vegge, Minhua Shao   +11 more
doaj   +1 more source

AI-driven digital circular economy with material and energy sustainability for industry 4.0

Energy and AI
Circular Economy and Sustainability in Industry 4.0 Era are promoters for carbon neutrality transformation, while their interconnected nexus and specific roles in low-carbon transition have not been clearly revealed.
Yuekuan Zhou
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Highly sensitive switching of solid-state luminescence by controlling intersystem crossing

Nature Communications, 2018
The development of intelligent materials, in particular those showing the highly sensitive mechanoresponsive luminescence (MRL), remains challenging. Here the authors report a strategy for constructing high performance On-Off MRL materials by introducing
Weijun Zhao, Zikai He, Qian Peng, Jacky W. Y. Lam, Huili Ma, Zijie Qiu, Yuncong Chen, Zheng Zhao, Zhigang Shuai, Yongqiang Dong, Ben Zhong Tang   +10 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Interfacial catalysis in lithium salt decomposition: Impacts on lithium metal battery performance

Future Batteries
Lithium metal batteries (LMBs) have emerged as the focal point of next-generation energy storage systems due to their high energy density and low electrochemical potential of the lithium metal anode.
Xiaosa Xu, Pengzhu Lin, Junjie Chen, Jin Li, Zhenyu Wang, Zixiao Guo, Jing Sun, Tianshou Zhao   +7 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Development process and future trends of chemical refining agents' influence on grain refinement in aluminum alloys

Journal of Materials Research and Technology
Aluminum is the world's largest production of non-ferrous metals, with light weight, high specific strength, excellent electrical and thermal conductivity and other characteristics.
Guoyan Liu, Yongsheng Ren, Wenhui Ma, Kazuki Morita, Yun Lei, Shu Zhan, Guoqiang Lv, Shaoyuan Li, Yi Zeng, Ruopu Li   +9 more
doaj   +1 more source

Estimating Historical Energy Security Costs [PDF]

Energy Security is of increasing importance in today’s world, yet little research has been carried out on the costs or benefits of energy security policies.
Arnold, Steve, Hunt, Alistair, Markandya, Anil   +2 more
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