Results 71 to 80 of about 1,368,548 (310)

Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer’s Disease Model

Cell Reports, 2016
Hippocampal synaptic plasticity is modulated by neuropeptides, the disruption of which might contribute to cognitive deficits observed in Alzheimer’s disease (AD).
Yang Shen, Min Tian, Yuqiong Zheng, Fei Gong, Amy K.Y. Fu, Nancy Y. Ip   +5 more
doaj   +1 more source

Knockdown of Dinoflagellate Condensin CcSMC4 Subunit Leads to S-Phase Impediment and Decompaction of Liquid Crystalline Chromosomes

Microorganisms, 2020
Dinoflagellates have some of the largest genomes, and their liquid-crystalline chromosomes (LCCs) have high degrees of non-nucleosomal superhelicity with cation-mediated DNA condensation.
Ting Hin Kosmo Yan, Zhihao Wu, Alvin Chun Man Kwok, Joseph Tin Yum Wong   +3 more
doaj   +1 more source

Clearing the Waters of the Fracking Debate [PDF]

Michigan Journal of Sustainability, 2013
Much of the debate on “fracking” in the United States is fueled by poor communication among stakeholders. Information in the public sphere may be provided by biased sources, and complicated academic research is often misinterpreted by media sources.
Ernstoff, Alexi, Ellis, Brian R.
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Observational Characterization of the Downward Atmospheric Longwave Radiation at the Surface in the City of São Paulo [PDF]

, 2010
This work describes the seasonal and diurnal variations of downward longwave atmospheric irradiance (LW) at the surface in São Paulo, Brazil, using 5-min-averaged values of LW, air temperature, relative humidity, and solar radiation observed continuously
Wilde Barbaro, E., Soares, J., Codato, G., Ferreira, M.J., Boznar, M.Z., Escobedo, J., Oliveira, A.P., Mlakar, P.   +7 more
core   +1 more source

Restoration of non-Hermitian bulk-boundary correspondence by counterbalancing skin effect

Communications Physics
In systems exhibiting the non-Hermitian skin effect (NHSE), the bulk spectrum under open boundary conditions (OBC) significantly differs from that of its periodic counterpart.
Yi-Xin Xiao, Zhao-Qing Zhang, C. T. Chan
doaj   +1 more source

Water-clear cell adenoma

International Journal of Surgery Case Reports, 2013
ABSTRACT INTRODUCTION: Primary hyperparathyroidism is a common endocrine disorder, with an incidence of 21.6 per 100,000 person-years. Asymptomatic elevated serum calcium levels on routine biochemical investigations accounts for 80% of newly diagnosed primary hyperparathyroidism.
Piggott, R.P., Waters, P.S., Ashraf, J., Colesky, F., Kerin, M.J.   +4 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Application of the CLeAR Approach to the Water Quality Domain [PDF]

, 2020
Dataset on the application of the CLeAR approach to the water quality domain. Each table provides data generated by a CLeAR step or activity.
Campos, P
core   +3 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source