Results 61 to 70 of about 1,846,891 (255)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]

, 2014
A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
core   +1 more source

An Investigation on the Effect of Endwall Movement on the Tip Clearance Loss Using Annular Turbine Cascade

International Journal of Rotating Machinery, 2011
The aerodynamic losses in gas turbines are mainly caused by profile loss secondary flow, and tip leakage loss. This study focuses on tip leakage flow of high-pressure turbine stages.
Hesham M. El-Batsh, Magdy Bassily Hanna
doaj   +1 more source

Beyond lactate: prognostic value of metabolic and biochemical parameters in methanol poisoning - a retrospective observational study. [PDF]

BMC Emerg Med
Background Methanol poisoning carries high mortality and morbidity, and early risk stratification in the emergency department (ED) remains challenging.
Ermete Güler E, Bora ES, Efgan MG, Bilgin S.   +3 more
europepmc   +2 more sources

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Genetic variation in the interleukin-28B gene is associated with spontaneous clearance and progression of hepatitis C virus in Moroccan patients [PDF]

, 2013
Genetic variation in the IL28B gene has been strongly associated with treatment outcomes, spontaneous clearance and progression of the hepatitis C virus infection (HCV).
Alaoui, Rihmou, Diepolder H., Salwa Nadir, Helmut Diepolder, Thursz, Mark, Sayeh Ezzikouri (143566), Khakoo Salim I., Mark Thursz, Soumaya Benjelloun (143569), Alaoui R., Alaoui Rhimou, Khakoo, Salim I., Mark Thursz (276871), Helmut Diepolder (276870), Nadir S., Ezzikouri Sayeh, Rebbani K., Nadir Salwa, Fakhir Fatima-Zohra, Fakhir F.-Z., Benjelloun, Soumaya, Benjelloun S., Fatima-Zohra Fakhir, Salim I Khakoo, Diepolder, Helmut, Thursz Mark, Nadir, Salwa, Benjelloun Soumaya, Brahim Ikram, Rhimou Alaoui, Rhimou Alaoui (276865), Brahim I., Diepolder, Helmut M., Sayeh Ezzikouri, Rebbani Khadija, Ikram Brahim, Alaoui, Rhimou, Rebbani, Khadija, Fatima-Zohra Fakhir (276868), Soumaya Benjelloun, Khadija Rebbani, Ikram Brahim (276867), Ezzikouri S., Salwa Nadir (276869), Khakoo S.I., Thursz M., Diepolder Helmut, Khadija Rebbani (276866), Salim I. Khakoo (201172), Fakhir, Fatima-Zohra, Ezzikouri, Sayeh, Brahim, Ikram   +51 more
core   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Maps and charts prepared by the Slum Clearance Committee of New York, 1933-34 : together with maps and charts of the Land Utilization Committee of the New York Building Congress as noted on the individual drawings included herein.

, 1934
Maps and charts prepared by the Slum Clearance Committee of New York, 1933-34.

core