Results 121 to 130 of about 742,813 (283)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
CLEARING THE AIR: DEBUNKING THE MYTH OF AIRBORNE SEXUALLY TRANSMITTED DISEASES
, 2023 Ashish Mehta +17 more
openalex +1 more source
The role and value of water in natural capital restoration on the Agulhas Plain [PDF]
The Agulhas Plain is a low-lying coastal area within the Cape Floristic Region classified as one of the six plant kingdoms of the world. The area is heavily invaded by alien vegetation that infringes upon the sustainable supply of ecosystem goods and ...
Albert van der Merwe +2 more
core
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Spring Books: Clearing the jungle of medical education [PDF]
, 1983 J. D. Swales
openalex +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Complex system testing based on API
Acta Polytechnica CTU ProceedingsThe article describes the practical experience of testing a specific ticketing system for public transport based on blockchain technology. The testing aimed to verify the overall functionality of the complex system as well as the correct execution of ...
Milan Sliacky, Lukáš Kacar
doaj +1 more source
SEASONAL LABOR CONSTRAINTS AND INTRA-HOUSEHOLD DYNAMICS IN THE FEMALE FIELDS OF SOUTHERN CAMEROON [PDF]
Women's agricultural production is modeled as a sequential switching regression process determined by men's clearing labor capacity and women's harvest labor capacity.
Elad, Renata L., Houston, Jack E.
core +1 more source