Results 101 to 110 of about 193,265 (306)

The Tessier Number 5 Facial Cleft: Surgical Strategies and Outcomes in Six Patients

open access: yes, 2009
The Tessier no. 5 facial cleft is an extremely rare congenital malformation. Only 26 cases have been described In the English-language literature. The cleft begins In the upper lip just medial to the oral commissure, extending across the cheek as a ...
SHIN, Joseph H.   +6 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Modified Dufourmentel Flap With Connective Tissue Grafting for Predictable Gingival Cleft Management: A Case Report

open access: yesClinical Case Reports
Presence of a gingival cleft and marginal tissue recession promotes microbial invasion into tissues by plaque accumulation, leading to inflammation; thus, reducing the stability of marginal tissues.
Ruchi Harish   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Antibiotic prophylaxis for the prevention of fistulae in cleft palate repair: A quality improvement study

open access: yesJPRAS Open
: Background: Post-operative infection following cleft palate repair can lead to wound dehiscence and subsequent fistula formation. To prevent this, many surgeons advocate using post-operative antibiotic prophylaxis.
Nitisha Narayan   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Factors associated with parental adaptation to having a child with a cleft lip and/or palate: the impact of parental diagnosis

open access: yes, 2012
Objective: To investigate the impact of parental diagnosis of cleft lip and/or palate (CL/P) on factors associated with parental adaptation to having a child with a cleft.
O'Hanlon, K., Shear, J., Camic, P.
core   +1 more source

A Novel Surgical Technique for Management of Congenital Midline Cervical Clefts: Case Series

open access: yesJournal of Plastic and Reconstructive Surgery
Congenital midline cervical cleft (CMCC) is a rare defect of the midline neck which is often misdiagnosed. The aim of this study is to show the efficacy and safety of a novel surgical technique for CMCC to get excellent aesthetic and functional results ...
Marta Cajozzo   +12 more
doaj  

A cleft in time

open access: yesThe Lancet Child & Adolescent Health, 2021
openaire   +3 more sources

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