BMJ Open, 2021 Objectives This study aimed to investigate the temporal and spatial characteristics of cleft lip and/or palate based on a large-scale birth defect monitoring database.Methods Data on perinatal infants and children with cleft lip and/or palate defects ...
Pi Guo +9 more
doaj +1 more source
Meta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene [PDF]
, 2016 Nonsyndromic orofacial clefts are common birth defects with multifactorial etiology. The most common type is cleft lip, which occurs with or without cleft palate (nsCLP and nsCLO, respectively).
Ahmed, S.T. (Syeda) +19 more
core +1 more source
Cleft Lip and Palate Treatment [PDF]
Plastic Surgery International, 2013 Cleft lip and palate is still a very challenging facial deformity, and this special issue has shown this very clearly. Many papers came from all around the world, and the topics were very up to date and have raised very interesting points. The topics about humanitarian mission and its role and the benefits are elucidated in these articles, but the ...
Alonso, Nivaldo +3 more
openaire +2 more sources
Distinct DNA methylation profiles in subtypes of orofacial cleft [PDF]
, 2017 Background Epigenetic data could help identify risk factors for orofacial clefts, either by revealing a causal role for epigenetic mechanisms in causing clefts or by capturing information about causal genetic or environmental factors.
Davey Smith, George +9 more
core +2 more sources
A cleft care workshop for speech and language pathologists in resource-limited countries : the participants' experiences about cleft care in Uganda and satisfaction with the training effect [PDF]
, 2020 Objectives: workshops and specialized training programs are often inaccessible for speech and language pathologists (SLPs) based in resource-limited countries given the lack of supply, the long travel distances and the excessive participation fees.
Alighieri, Cassandra +7 more
core +2 more sources
An update on the aetiology of orofacial clefts [PDF]
, 2004 Objective. To review recent data on the aetiology of cleft lip and palate. Data sources. MEDLINE literature search (1986-2003). Study selection. Literature and data on aetiology of cleft lip and palate using the following key words: 'cleft lip', 'cleft ...
Hägg, U, Wong, FK
core
Novel GREM1 Variations in Sub-Saharan African Patients With Cleft Lip and/or Cleft Palate [PDF]
, 2018 Objective: Cleft lip and/or cleft palate (CL/P) are congenital anomalies of the face and have multifactorial etiology, with both environmental and genetic risk factors playing crucial roles.
Abdur-Rahman, Lukman O. +23 more
core +3 more sources
Advanced Science, EarlyView.Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong +19 more
wiley +1 more source
Retrospective longitudinal analysis of phonetic and phonological cleft palate speech characteristics [PDF]
, 2015 In this study, we analysed phonetic and phonological consonant characteristics of cleft palate speech (CPS) at ages 5 and 10 in cleft palate with/without cleft lip (CP±CL) based on Cleft Audit Protocol for Speech – Augmented (CAPS-A) data collected in ...
Cohen, Wendy +3 more
core
Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity
Advanced Science, EarlyView.A correlative imaging platform is developed to study how individual taste cells respond to different taste qualities. By linking cellular activity with molecular identity and environmental context, dual‐tuned taste cells capable of detecting both sweet and umami stimuli are identified.
Sungho Lee +6 more
wiley +1 more source