Results 71 to 80 of about 59,855 (260)

Identification of major congenital malformations based on healthcare databases in France: A proof‐of‐concept study using the epi‐meres nationwide mother–child register

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Besides registries, healthcare databases can provide useful information for assessing the frequency of major congenital malformations (MCMs) and investigating their risk factors, particularly medication exposures. This study aimed to assess the validity of MCMs identification based on French national, comprehensive healthcare databases ...
Tom Duchemin, Lise Marty, Jérôme Drouin, Sara Miranda, Jérémie Botton, Valérie Olié, Alain Weill, Rosemary Dray‐Spira   +7 more
wiley   +1 more source

All-Trans Retinoic Acid Impacts Early Palatal Shelves Development via the Wnt and TGF-β Signaling Pathways

Biomedicines
Background/Objectives: All-trans retinoic acid (atRA), a potent derivative of vitamin A, is recognized as a significant teratogen for inducing cleft palate in both humans and mice.
Yaping Ma, Binqing Wang, Shikang Gao, Tao Song   +3 more
doaj   +1 more source

Post-surgical dentofacial deformities and dental treatment needs in cleft-lip-palate children: A clinical study

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2011
Background: Cleft lip and palate is a common congenital defect. It is one of the most common facial deformities occurring in major racial and ethnic groups.
V Krishna Priya, J Sharada Reddy, Y Ramakrishna, C Pujita Reddy   +3 more
doaj   +1 more source

Local expression of inflammatory cytokines in the facial tissue of children with a cleft lip and palate [PDF]

, 2012
The cleft lip and/or palate are among the most common congenital anomalies that occur in early development. Cytokines play an important role in the proliferation, growth, differentiation, survival and the functional activity of many cells and the ...
Akota, Ilze, Pilmane, Mara, Smane, Liene
core   +3 more sources

Implant‐related orofacial pain managed with implant apicoectomy: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background In recent years, the use of implants has emerged as a widely accepted method for the replacement of missing teeth. Although rare, chronic pain associated with implant placement has been reported in the literature. Conversely, apicoectomy, the removal of the apical portion has been integrated into the implantology field in cases with
Oscar Durán‐Garnica, Karen Villarreal‐Arizpe, Hong Chen, Hsun‐Liang Chan, Guo‐Liang Cheng   +4 more
wiley   +1 more source

Accumulation of rare coding variants in genes implicated in risk of human cleft lip with or without cleft palate. [PDF]

, 2019
Cleft lip with/without cleft palate (CLP) is a common craniofacial malformation with complex etiologies, reflecting both genetic and environmental factors. Most of the suspected genetic risk for CLP has yet to be identified. To further classify risk loci
Asrani, Kripa, Marini, Nicholas J, Rine, Jasper, Shaw, Gary M, Yang, Wei   +4 more
core   +2 more sources

Identification of novel genes regulating the development of the palate

Developmental Dynamics, EarlyView.
Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley   +1 more source

A combined targeted mutation analysis of IRF6 gene would be useful in the first screening of oral facial clefts [PDF]

, 2013
BACKGROUND: Interferon Regulatory Factor 6 (IRF6) is a member of the IRF family of transcription factors. It has been suggested to be an important contributor to orofacial development since mutations of the IRF6 gene has been found in Van der Woude (VWS)
Chun-Shin Frank Chang, Kuo-Ting Philip Chen, Lun-Jou Lo, Yah-Huei Wu-Chou, Yu-Ray Chen   +4 more
core   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Pilot epidemiological study of cleft lip and/or palate inh Kota Kinabalu, Sabah

Asian Journal of Medical Sciences, 2013
Objective: To identify number of cases and the type of cleft lip and/or palate managed in government tertiary center (Queen Elizabeth Hospital) in Kota Kinabalu; and to analyze the associative factors of cleft lip and/or palate.
Chai Siew Cheng
doaj   +1 more source