Results 71 to 80 of about 2,234,265 (385)
Advanced Science, EarlyView.Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang +18 more
wiley +1 more source
Some Potential Issues with the Security of HTML5 IndexedDB [PDF]
, 2014 The new HTML5 standard provides much more access to client resources, such as user location and local data storage. Unfortunately, this greater access may create new security risks that potentially can yield new threats to user privacy and web attacks ...
Ellman, Jeremy +2 more
core +1 more source
Advanced Science, EarlyView.Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun +14 more
wiley +1 more source
Advanced Science, EarlyView.This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong +15 more
wiley +1 more source
Self management of a mobile thin client service [PDF]
, 2009 Mobile thin client computing is an enabler for the execution of demanding applications from mobile handhelds. In thin client computing, the application is executed on remote servers and the mobile handheld only has to display the graphical updates and ...
De Turck, Filip +5 more
core +1 more source
Advanced Science, EarlyView.BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou +9 more
wiley +1 more source
Ethical Issues in Mass Tort Plaintiffs’ Representation: Beyond the Aggregate Settlement Rule [PDF]
, 2013 Those who have addressed ethics issues for plaintiffs’ lawyers in mass tort litigation have focused on possible reform of the aggregate settlement rule to facilitate global settlements. This Article addresses a broader range of ethical issues, including
Moore, Nancy J.
core +2 more sources
A molecular mechanism of chaperone-client recognition
Science Advances, 2016 Conformation and dynamics of a chaperone-client interaction at the atomic level show a basic underlying mechanism. Molecular chaperones are essential in aiding client proteins to fold into their native structure and in maintaining cellular protein ...
Lichun He +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu +14 more
wiley +1 more source
Polyamines delay leaf maturation in low‐alkaloid tobacco varieties
Plant Direct, 2018 The development of low‐alkaloid (LA) tobacco varieties is an important target in the tobacco breeding industry. However, LA Burley 21 plants, in which the Nic1 and Nic2 loci controlling nicotine biosynthesis are deleted, are characterized by impaired ...
Greta Nölke +12 more
doaj +1 more source