Results 191 to 200 of about 22,244,527 (244)

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Overnight sleep features and next-morning brain metabolism in older adults. [PDF]

Sleep Med
Carvalho DZ, Adolf J, Kremen V, McCarter SJ, St Louis EK, Przybelski SA, Liu K, Jones DT, Petersen RC, Jack CR, Lowe VJ, Varga AW, Somers VK, Graff-Radford J, Grinberg LT, Boeve BF, Worrell GA, Vemuri P.   +17 more
europepmc   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Prophylactic Enoxaparin Dosing After Bariatric Surgery: A Systematic Review and Meta-Analysis of Pharmacodynamic Efficacy and Safety. [PDF]

Obes Surg
Kennedy C, Al Azzawi M, Davey M, Clifford JT, Butt W, Donlon N, Murphy K, Fearon N, Heneghan H.   +8 more
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Prenatal air pollution exposure is associated with altered neurodevelopmental outcomes in early childhood

The Journal of Physiology, EarlyView.
Abstract figure legend This study examined the effect of modelled maternal air pollution exposure during gestation on neurodevelopment in a community cohort of 498 toddlers recruited from Greater London, UK. Higher 1st trimester exposure to particulate matter and nitrogen dioxide was associated with lower language scores at 18 months adjusting for ...
Alexandra F. Bonthrone, Brendan Bos, Ben Barratt, Hoi Ching Olina Pang, Sean Beevers, Andrew Chew, Shona Falconer, Joseph V. Hajnal, Frank J. Kelly, Chiara Nosarti, A. David Edwards, Serena J. Counsell   +11 more
wiley   +1 more source

Secondary anticoagulation prophylaxis for children with antiphospholipid syndrome: a systematic review and meta-analysis. [PDF]

Blood Adv
Kawtharany H, Azzam M, Khawandi J, Hamarsha Q, Choaib A, Alkhader A, Nazzal J, Alkasrawi H, Khanfar O, Kumar R, Sartain SE, Betensky M, Monagle P, Mustafa RA, ASH/ISTH VTE Prophylaxis Pediatrics Guideline Group.   +14 more
europepmc   +1 more source

Antiviral defenses are diminished at birth in cystic fibrosis pig airways. [PDF]

J Cyst Fibros
Bartlett JA, Ortiz ME, Powers LS, Wohlford-Lenane CL, Hippee CE, Marquez Loza L, Kaufman JW, Singh BK, Sands DI, Huntemann ED, Cooney AL, Rogan MP, Taggart CC, Meyerholz DK, McCray PB.   +14 more
europepmc   +1 more source

Distribution and Abundance of the Bioeroding Sponge Cliona sp. in Oyster Populations of Ostrea chilensis Across New Zealand

New Zealand Journal of Marine and Freshwater Research, Volume 60, Issue 4, December 2026.
Bioeroding sponges are recognised pests in shellfish fisheries, as their boring activity can reduce market value, contribute to oyster mortality and cause economic losses. In New Zealand, bioeroding sponges in the shell‐burrowing alpha form are frequently observed in shells of the flat oyster Ostrea chilensis, a historically and culturally important ...
Imke M. Böök, Keith P. Michael, Christopher E. Cornwall, James J. Bell, Nicole E. Phillips   +4 more
wiley   +1 more source

Effects of hypertonic saline and/or carbocisteine on sputum rheology in bronchiectasis: CLEAR-EME. [PDF]

ERJ Open Res
McKelvey MC, Einarsson GG, Carson J, Kadoom A, Brown RR, Campbell C, Jackson A, McDowell C, Clarke M, Copeland F, Ferguson K, McLeese RH, Convery R, Hill AT, De Soyza A, Shahidi M, Kelly M, Carroll M, Gatheral T, Anwar M, Duckers J, Flight W, Hurst JR, Ionescu AA, Loebinger MR, Sullivan AL, Chalmers JD, Downey DG, Tunney MM, O'Neill B, McAuley DF, Elborn JS, Bradley JM, Taggart CC.   +33 more
europepmc   +1 more source