Results 41 to 50 of about 11,049,619 (312)

Characterisation of ethylene pathway components in non-climacteric capsicum [PDF]

, 2013
Background: Climacteric fruit exhibit high ethylene and respiration levels during ripening but these levels are limited in non-climacteric fruit. Even though capsicum is in the same family as the well-characterised climacteric tomato (Solanaceae), it is ...
Aizat, W., Able, A., Stangoulis, J., Able, J.   +3 more
core   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Ethylene signalling receptors and transcription factors over the grape berry development: gene expression profiling [PDF]

, 2010
The ethylene signalling pathway has never been fully described in grapes. Regarded as a non-climacteric fruit, grape berry seems to ripen independently to ethylene, however 1-methylcyclopropene (1-MCP), a specific inhibitor of ethylene receptors has been
Chervin, Christian, Chervin, D., Deluc, Laurent, Deluc, L., Chervin, C.   +4 more
core   +1 more source

The role of self-rated health in the association between chronic somatic diseases and climacteric-related symptoms

, 2022
Objectives: We have previously shown an association between several chronic somatic diseases and climacteric-related symptoms. This time, we investigated whether self-rated health (SRH) contributes to this association.Methods: The Women's Health ...
Polo-Kantola P, Erkkola RU, Engblom JR, Katainen RE, Siirtola TJ   +4 more
core   +1 more source

Animal stroke models and outcome evaluation: A review

Animal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba, Helen M. Atkinson, Anthony K. C. Chan   +2 more
wiley   +1 more source

Pelvic breadth and juvenile locomotor energetics: Implications for the obstetrical dilemma hypothesis across human growth in past and present humans

The Anatomical Record, EarlyView.
Abstract The obstetrical dilemma hypothesis (ODH) proposes an evolutionary trade‐off between obstetric requirements and locomotor performance. However, whether external pelvic breadth measures influence walking energetics during human growth remains poorly understood.
Guillermo Zorrilla‐Revilla, Olalla Prado‐Nóvoa, Kevin P. Davy, José Miguel Carretero, Rebeca García‐González   +4 more
wiley   +1 more source

Quality of life as an indicator of connective tissue condition in women with metabolic syndrome without estrogen support

Сибирский научный медицинский журнал
In modern medicine, the relevance of the problem associated with the aging of the female body is undeniable. Due to the decrease in the intensity of secretion of sex steroids, the addition of metabolic syndrome is accompanied by processes which can ...
E. S. Krutikov, Z. S. Rumyantseva, N. S. Tribrat, E. Yu. Zyablitskaya, V. B. Demyanova, G. A. Puchkina, N. V. Efremova, A. A. Gorbunov   +7 more
doaj   +1 more source

Greene Climacteric Scale: norms in an Australian population in relation to age and menopausal status

, 2005
Objectives The aim of this study was two-fold: to assess climacteric symptoms and provide normative data for the Greene Climacteric Scale during the menopause transition, and to investigate the prevalence of climacteric symptoms in a representative ...
Khoo, Soo, Travers, Catherine, Battistutta, D., Battistutta, Diana, O'Neill, S. M., Travers, C., King, R., O'Neill, Sheila, Khoo, S. K., King, Robert   +9 more
core   +1 more source

Study on differential expression of 1-aminocyclopropane-1-carboxylic acid oxidase genes in table grape cv. Thompson Seedless [PDF]

, 2013
As a consequence of the non-climacteric status of grapes (Vitis vinifera), ethylene biosynthesis and signal transduction have scarcely been studied in this fruit.
González-Agüero, Mauricio, Defilippi, Bruno G., Chervin, Christian, Gudenschwager, Orianne, Munoz-Robredo, Pablo, Campos-Vargas, Reinaldo   +5 more
core   +1 more source