Results 251 to 260 of about 879,580 (295)

Dual‐Key Genetic Circuit Enables Stable and Self‐Regulated Engineered Bacteria for the Treatment of Ulcerative Colitis

Advanced Science, EarlyView.
A self‐regulated Escherichia coli Nissle 1917 strain equipped with a dual‐key genetic circuit achieved antibiotic‐free stability and programmable lysis for therapeutic protein delivery. By co‐expressing an IL‐2 mutant and Amuc_1100, the engineered bacteria restored immune balance and epithelial integrity, providing a safe and precise approach for ...
Shuaijie Ding, Biao Yang, Xinyu Li, Yi Wang, Chunyu Huang, Wenfei Dong, Wei Xie   +6 more
wiley   +1 more source

Cowpea (Vigna unguiculata L. Walp.) landraces in Mozambique and neighbouring Southern African countries harbour genetic loci with potential for climate adaptation. [PDF]

Commun Biol
Macharia MW, Caproni L, Solemanegy M, Takele R, Chiulele RM, Munisse P, Amane M, Pè ME, Buizza R, Dell'Acqua M.   +9 more
europepmc   +1 more source

Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli

Advanced Science, EarlyView.
An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng, Hao Liu, Haolin Han, Meng Meng, Shaojie Wang, Tianwei Tan, Haijia Su   +6 more
wiley   +1 more source

Genetic admixture drives climate adaptation in the bank vole. [PDF]

Commun Biol
Horníková M, Lanier HC, Marková S, Escalante MA, Searle JB, Kotlík P.   +5 more
europepmc   +1 more source

Centering voices of scientists from marginalized backgrounds to understand experiences in climate adaptation science and inform action. [PDF]

PLoS One
Marjadi MN, Smith RA, Tu HF, Ajmani AM, Holland AR, Lopez BE, Morelli TL, Bradley BA.   +7 more
europepmc   +1 more source

Institutional logics as an object of change: the experiences of a water organization using design thinking for climate adaptation in a multi-stakeholder process. [PDF]

Sustain Sci
Goldschmeding F, Kemp R, Vasseur V, Scholl C.   +3 more
europepmc   +1 more source

The association between gender equality and climate adaptation across the globe. [PDF]

BMC Public Health
Pinho-Gomes AC, Woodward M.
europepmc   +1 more source

Genomic signatures of climate adaptation in bank voles. [PDF]

Ecol Evol
Folkertsma R, Charbonnel N, Henttonen H, Heroldová M, Huitu O, Kotlík P, Manzo E, Paijmans JLA, Plantard O, Sándor AD, Hofreiter M, Eccard JA.   +11 more
europepmc   +1 more source