Results 251 to 260 of about 897,845 (317)

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Not Enough to Meet a Growing Threat: A Scoping Review of Climate Adaptation and Intervention Strategies in Health Facilities across Low- and Middle- Income Countries

Oguta JO, Nakstad B, Ochieng S, Akoth C, Toweet SK, Pinchoff J, Mohamoud G, Muchangi JM, Pagiwa V, Lusambili A.   +9 more
europepmc   +1 more source

Structures and systems that promote nutrition security and climate adaptation in Puerto Rico: results from community-based system dynamics. [PDF]

Public Health Nutr
Colón-Ramos U, Guerra Uccelli N, Meléndez-Colón O, García Blanco AM, Ostolaza Santiago C, Rosas Pérez C, Gomez Andújar N, Tavárez H, Poirier L, Gittelsohn J, Long MW.   +10 more
europepmc   +1 more source

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

Signature of Selection Analysis Reveals Candidate Genes Related to Climate Adaptation and Production Traits in Lao Native Goats. [PDF]

J Anim Breed Genet
Le SV, Alexandri P, van der Werf JHJ, Olmo L, Walkden-Brown SW, de Las Heras-Saldana S.   +5 more
europepmc   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

AI-Powered Plant Science: Transforming Forestry Monitoring, Disease Prediction, and Climate Adaptation. [PDF]

Plants (Basel)
Xu Z, Jiang D.
europepmc   +1 more source

Thin‐Film Thermal Sensors on Chitosan Substrates for Sustainable Transient Electronics

Advanced Electronic Materials, EarlyView.
Fully transient thin‐film temperature sensors are realized on pure chitosan substrates using Mo‐based RTDs and a‐IGZO/Mo thermistors. The devices exhibit high sensitivity, mechanical flexibility, humidity‐aware operation, and complete dissolution in natural solvents.
Ahmed Rasheed, Soufiane Krik, Sundus Riaz, Hafiza Faiqa Maqsood, Jacopo Nicoletti, Riccardo Zamboni, Guglielmo Trentini, Pietro Ibba, Franco Cacialli, Andrea Gaiardo, Giuseppe Cantarella, Niko Münzenrieder, Paolo Lugli, Giovanni Antonio Salvatore, Luisa Petti   +14 more
wiley   +1 more source

Urban Greenspace, Climate Adaptation and Health Co-Benefits: Municipal Policy and Practice in London. [PDF]

Int J Environ Res Public Health
Turcu C.
europepmc   +1 more source