Results 251 to 260 of about 3,056,878 (315)

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Haploblocks contribute to parallel climate adaptation following global invasion of a cosmopolitan plant. [PDF]

Nat Ecol Evol
Battlay P, Hendrickson BT, Mendez-Reneau JI, Santangelo JS, Albano LJ, Wilson J, Caizergues AE, King N, Puentes A, Tudoran A, Violle C, Vasseur F, Patterson CM, Foster M, Stamps C, Innes SG, Allio R, Angeoletto F, Anstett DN, Anstett J, Bucharova A, Comerford MS, David S, Falahati-Anbaran M, Godsoe W, González-Lagos C, Gundel PE, Hood GR, Lampei C, Lara C, Lázaro-Lobo A, Silva Leandro D, Merritt TJS, Mitchell N, Mohammadi Bazargani M, Moles A, Murúa M, Paule J, Pfeiffer V, Raeymaekers JAM, Rennison DJ, Rios RS, Rowntree JK, Schneider AC, Stack Whitney K, Tamburrino Í, VanWallendael A, Kim PY, Ness RW, Johnson MTJ, Hodgins KA, Kooyers NJ.   +51 more
europepmc   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Climate adaptation in Populus trichocarpa: key adaptive loci identified for stomata and leaf traits. [PDF]

New Phytol
Klein MC, Meng Z, Bailey-Bale J, Milner S, Shi P, Muchero W, Chen JG, Tschaplinski TJ, Jacobson D, Lagergren J, Lane M, O'Brien C, Chhetri H, Abeyratne CR, Shu M, Freer-Smith P, Buckley TN, Magney TS, Monroe JG, Tuskan GA, Taylor G.   +20 more
europepmc   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

Whole Genome Resequencing Reveals the Genetic Basis of Desert Arid Climate Adaptation in Lop Sheep. [PDF]

Animals (Basel)
Yang C, Gong C, Khamili A, Li X, Gao Q, Chen H, Xiang X, Wang J, Han C, Gao Q.   +9 more
europepmc   +1 more source

Narratives of climate adaptation and linkages to psychosocial and nutritional health in a Zimbabwean rural community. [PDF]

World Dev Sustain
Bhatasara S, Nwosu C, Macheka L, Nyamwanza AM.   +3 more
europepmc   +1 more source

Thermal Vulnerability and Potential Cultivation Areas of Four Day-Neutral Strawberries in Chile: Implications for Climate Adaptation. [PDF]

Plants (Basel)
Sierra-Almeida A, Morales LV, Guerrero D, Hasbún RJN, Retamal L, Garrido-Bigotes A, Tamburrino Í, Maruri A.   +7 more
europepmc   +1 more source

International climate adaptation assistance: Assessing public support in Switzerland. [PDF]

PLoS One
Andonova L, Zucca A, Montfort S, Dolšak N, Prakash A.   +4 more
europepmc   +1 more source

Temperature-Photoperiod Interaction in Rice Phenology for Climate Adaptation: Insights Into Glycerate-Associated Metabolic Responses. [PDF]

Physiol Plant
Lee HS, Kim JH, Jo SH, Yang SY, Baek JK, Song YS, Shon JY, Chung NJ.   +7 more
europepmc   +1 more source