Results 71 to 80 of about 360,749 (304)

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

The Psychosocial Work Environment, Employee Mental Health and Organizational Interventions: Improving Research and Practice by Taking a Multilevel Approach [PDF]

, 2014
Although there have been several calls for incorporating multiple levels of analysis in employee health and wellbeing research, studies examining the interplay between individual, workgroup, organizational and broader societal factors in relation to ...
Arnetz, Bacharach, Bamberger, Biron, Biron, Biron, Biron, Bliese, Bliese, Bonde, Bourbonnais, Bourbonnais, Briner, Burke, Capelli, Chan, Clegg, Clegg, Cole, Cooper, Cox, Dawkins, De Silva, Demerouti, Dextras-Gauthier, Diez-Roux, Dollard, Dollard, Dollard, Dollard, Dollard, Dollard, Ferrie, Giga, Goldenhar, Graveling, Greenberg, Hackman, Hall, Hargrove, Hofmann, Hurrell, James, James, Jauvin, Johns, Karanika-Murray, Karasek, Katz-Navon, Kelloway, Klein, Klein, Kolstad, Kompier, Kuenzi, Kulik, Lamontagne, Lamontagne, Li, Maloney, Marchand, Martin, Melchior, Mellor, Mischel, Mitchell, Murphy, Newman, Nicholson, Nielsen, Nielsen, Oakley, Ostroff, Patterson, Pawson, Peterson, Pignata, Probst, Quick, Randall, Reichers, Rousseau, Rousseau, Rousseau, Saksvik, Schein, Schminke, Schneider, Schneider, Schneider, Schyns, Seibert, Semmer, Siegrist, Sorensen, Spell, Stansfeld, Taris, Ukoumunne, Van Yperen, Waldenstrom, Walsh, Walumbwa, Weick, Ylipaavalniemi, Zohar   +105 more
core   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

From ‘motivational climate’ to ‘motivational atmosphere’: a review of research examining the social and environmental influences on athlete motivation in sport [PDF]

, 2010
This chapter is intended to provide a comprehensive review of the various theories of social and environmental factors that influence athletes’ motivation in sport.
Harwood, Chris, Keegan, Richard, Lavallee, David, Spray, Christopher   +3 more
core  

Sustainability, transport and design: reviewing the prospects for safely encouraging eco-driving

, 2013
Private vehicle use contributes a disproportionately large amount to the degradation of the environment we inhabit. Technological advancement is of course critical to the mitigation of climate change, however alone it will not suffice; we must also see ...
Harvey, Catherine, McIlroy, R., Robertson, Duncan, Stanton, Neville A.   +3 more
core   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Digital Threat: The Influence of Social Media Use on Climate Anxiety in Emerging Adulthood Moderated by Gender

Psikologika: Jurnal Pemikiran dan Penelitian Psikologi
Several studies have investigated the mental health impacts of climate change, with only a few examining the effect of social media use on climate anxiety.
Vania Ardelia, Siti Jaro'ah
doaj   +1 more source

Destructive Effects of Constructive Ambiguity in Risky Times [PDF]

, 2010
Unclear bailout policy, underinvestment and calls for bankers? responsibility are some of the observations from the recent financial crisis. The paper explains underinvestment as an inefficient equilibrium.
Vinogradov, D
core  

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Higher levels of eco-distress in psychotherapy out-patients with depressive and anxious symptoms are predicted by emotion regulation strategies

Frontiers in Psychiatry
BackgroundPsychotherapy patients are particularly vulnerable to the experience of eco-distress, often referred to as climate anxiety or eco-anxiety.
Nadja Gebhardt, Jil Beckord, Jil Beckord, Alexander Bäuerle, Alexander Bäuerle, Martin Teufel, Martin Teufel, Hans-Christoph Friederich, Hans-Christoph Friederich, Christoph Nikendei   +9 more
doaj   +1 more source