Results 81 to 90 of about 360,749 (304)

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

The relationship between right-wing ideological attitudes and psychological well-being [PDF]

, 2013
The relationship between right-wing ideological attitudes and psychological well-being has been intensively studied. While some studies supported the hypothesis that right-wing attitudes are negatively related with well-being, other research yielded ...
Dhont, Kristof, Onraet, Emma, Van Hiel, Alain   +2 more
core   +1 more source

The climate anxiety compass: A framework to map the solution space for coping with climate anxiety

Dialogues on Climate Change
Witnessing the rapidly unfolding consequences of climate change, many people feel worried, stressed and anxious. While many suggestions on how to cope with climate anxiety have been proposed, the literature lacks a theory-informed framework that structures and integrates different coping strategies.
van Valkengoed, Anne, Steg, Linda
openaire   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

\u3ci\u3eClimate, Complacency and American Culture: The Role of Narrative in the Era of the Misinformation Amid the Anthropocene\u3c/i\u3e [PDF]

, 2020
This article explores the relationship between climate misinformation campaigns and narratives in light of skepticism and denial of climate change in the era of the Anthropocene.
Batalha, Kayla
core   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Climate anxiety in early childhood: A state-of-the-art review

Journal of Childhood, Education & Society
As the climate crisis intensifies, young children are increasingly exposed to psychological stress linked to environmental change, manifesting in emerging forms of anxiety, sadness, and guilt. Although climate anxiety in children is gaining international
Jane Spiteri
doaj   +1 more source

Sustaining Autonomous Communities in the Modern United States (The United Communities of America) [PDF]

, 2017
America has become industrialized and characterized by social anxiety and overconsumption. The inability to be sustainable has led the once plentiful and flourishing nation into an ongoing sustainability crisis. Even if there is a deep connection between
Hester, Lucas
core   +1 more source

Globalisation, inequality and climate change: what difference does China make? [PDF]

, 2008
The deepening of globalisation in the late 20th century saw accelerating climate change, growing inequality and obstinate levels of poverty, not just in low-income economies, but also in the European Union and the rest of the high-income world.
Kaplinsky, Raphael
core   +1 more source