Results 211 to 220 of about 804,342 (282)

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

Prioritization of Older Adults in Canadian Climate Change Adaptation Policies: A Policy Document Analysis. [PDF]

J Am Geriatr Soc
Katz GM, Jain A, Kokorelias KM, Stall NM.   +3 more
europepmc   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Investigating disater risk management and climate change adaptation effectiveness in freetown, Sierra Leone.

Jamba
Sam-Mbomah E, Chmutina K, Smith A, Goodall S, Bosher L.   +4 more
europepmc   +1 more source

Indigenous knowledge and leadership for climate change adaptation in nutrition. [PDF]

PLOS Glob Public Health
Zavaleta-Cortijo C, Silvera-Ccallo R, Lancha-Rucoba G, Chanchari J, Inuma N, Pizango M, Morales-Ancajima V, Miranda-Cuadros M, Aparco JP, Valdivia-Gago A, Nunta-Guimaraes R, Antazú T, Velez-Quevedo J, Fernandez-Neyra C, Carcamo C, Greenwood D, Cade J, Ford JD, Harper S, Miranda JJ.   +19 more
europepmc   +1 more source

Dual‐Key Genetic Circuit Enables Stable and Self‐Regulated Engineered Bacteria for the Treatment of Ulcerative Colitis

Advanced Science, EarlyView.
A self‐regulated Escherichia coli Nissle 1917 strain equipped with a dual‐key genetic circuit achieved antibiotic‐free stability and programmable lysis for therapeutic protein delivery. By co‐expressing an IL‐2 mutant and Amuc_1100, the engineered bacteria restored immune balance and epithelial integrity, providing a safe and precise approach for ...
Shuaijie Ding, Biao Yang, Xinyu Li, Yi Wang, Chunyu Huang, Wenfei Dong, Wei Xie   +6 more
wiley   +1 more source

Socio-economic factors constrain climate change adaptation in a tropical export crop. [PDF]

Nat Food
Varma V, Mosedale JR, Alvarez JAG, Bebber DP.   +3 more
europepmc   +1 more source

Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli

Advanced Science, EarlyView.
An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng, Hao Liu, Haolin Han, Meng Meng, Shaojie Wang, Tianwei Tan, Haijia Su   +6 more
wiley   +1 more source

Disentangling climate change adaptation: A multi-site comparison of constraints and opportunities among Indigenous Peoples and local communities

Schlingmann A, Waha K, Álvarez-Fernández S, Attoh EM, Carmona R, Chakauya R, Fernández-Llamazares Á, Izquierdo AE, Junqueira AB, Lanker M, Porcuna-Ferrer A, Torrents-Ticó M, Benyei P, Borghesi F, Codina MR, Reyes-García V.   +15 more
europepmc   +1 more source