Results 91 to 100 of about 330,004 (297)

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Climate anxiety as a call to global justice

Frontiers in Psychology
Climate anxiety (or eco-anxiety) is a growing psychological phenomenon linked to the increasing awareness of the environmental crisis caused by climate change.
Batul Hanife, Paolo Cianconi, Francesco Grillo, Alexis Paulinich, Luigi Janiri   +4 more
doaj   +1 more source

From ‘motivational climate’ to ‘motivational atmosphere’: a review of research examining the social and environmental influences on athlete motivation in sport [PDF]

, 2010
This chapter is intended to provide a comprehensive review of the various theories of social and environmental factors that influence athletes’ motivation in sport.
Harwood, Chris, Keegan, Richard, Lavallee, David, Spray, Christopher   +3 more
core  

Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways

Advanced Science, EarlyView.
This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li, Huiyang Huang, Cunhao Hu, Xuan Zhang, Song Lin, Xiaodan Huang, Ti‐fei Yuan, Kwok‐Fai So, Lu Huang, Chaoran Ren, Qian Tao   +10 more
wiley   +1 more source

Climate Change Awareness, Eco-Anxiety, and Anger among Yemeni Medical Students.

Iranian Journal of Psychiatry
Objective: Climate change is increasingly recognized as a global health threat. However, awareness and psychological responses to climate risks may vary across populations, particularly in conflict-affected regions. This study aimed to assess the levels
Asma Taha Ali Al-Taheri, Hebah Yassin Abduljabar Alsabiea, Tharwa Ghaleb Hassan Al-Barakani, Manal Ali Ahmed, Futoun Mohsen Alkhulagi   +4 more
doaj   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Does concern regarding climate change impact subsequent mental health? A longitudinal analysis using data from the Avon Longitudinal Study of Parents and Children (ALSPAC)

Royal Society Open Science
Climate change is having a substantial—and increasingly severe—impact on our planet, affecting people’s health, security and livelihoods. As a consequence, the concept of ‘climate anxiety’ has recently been developed to characterize the psychological and
Daniel Major-Smith, Isaac Halstead, Katie Major-Smith   +2 more
doaj   +1 more source

Regional variation in perceptions about climate change. [PDF]

, 2009
A 2007 survey covering rural areas in nine US states provides data on perceived local impacts of climate change. Perceptions vary from region to region, with a pattern suggesting links to real climate specifically to winter warming in snow country.
Hamilton, Lawrence C., Keim, Barry D.
core   +2 more sources

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source