Results 121 to 130 of about 18,751,832 (408)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Clinical Conditions Associated With a High Antinuclear Antibody Titer in Individuals Without Autoimmune Disease

Arthritis Care &Research, EarlyView.
Objective Antinuclear antibodies (ANAs) are present at high titers in 2% of the general population, but their clinical significance in individuals without an autoimmune (AI) disease is not known. We tested the hypothesis that the presence of a high ANA titer in non‐AI conditions is associated with disease.
Matthew Chung, John P. Shelley, Gul Karakoc, John Still, Xiaodi Ruan, Jonathan Mosley, C. Michael Stein, Vivian K. Kawai   +7 more
wiley   +1 more source

Performance of water quality simulation model for lifting drainage water joints and mixing zone determination

Applied Water Science
Limited water resources with gradual increase in water demand led to higher dependence on drainage water as one of the non-conventional water resources in Egypt. However, there was no precise approach for using such resource. The practices ranged between
Talaat El-Gamal, Asmaa Agrama
doaj   +1 more source

Activating the role of women in water projects

Water Science, 2014
Water is one of our most precious natural resources. A growing human population, and the expansion of economic activities that comes with it, will intensify the pressure on water resources.
Mohammed T. Kholif, Ahmed M. Elfarouk
doaj   +1 more source

Erratum to: Climate change, weather shocks, and price convergence in pre-industrial Germany [PDF]

, 2021
Hakon Albers, Ulrich Pfister
openalex   +1 more source

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) Network investigators   +14 more
wiley   +1 more source

Early Danian paleotemperature records from Neuquén Basin-Argentina: Applications of the ostracod Sr/Ca paleothermometer

Evolving Earth
The early Danian is marked by a recovery in marine and terrestrial ecosystems after the Cretaceous-Paleogene mass extinction. Both sea surface temperature (SST) and bottom water temperature (BWT) reconstructions are essential for a better understanding ...
Marlone H.H. Bom, Karlos G.D. Kochhann, Rodrigo do Monte Guerra, Daiane Ceolin, Guilherme Krahl, Luciana R.C. Duarte, Mírian L.A.F. Pacheco, Thorsten Bauersachs, Luiz Frederico Rodrigues, Flavia Callefo, Franciele Agnesa Trentin, Douglas Galante, Telma Musso, Lorenz Schwark, Andrea Concheyro, Gerson Fauth   +15 more
doaj   +1 more source

Sources of black carbon to the Himalayan–Tibetan Plateau glaciers

Nature Communications, 2016
Black carbon accelerates melting of glaciers in the Himalayas and Tibet, yet the source of these aerosols remains enigmatic. Here, the authors use isotope fingerprinting techniques to determine the origin of black carbon preserved in glacier ice cores ...
Chaoliu Li, Carme Bosch, Shichang Kang, August Andersson, Pengfei Chen, Qianggong Zhang, Zhiyuan Cong, Bing Chen, Dahe Qin, Örjan Gustafsson   +9 more
doaj   +1 more source

Cognitive Behavioral Therapy for Youth With Childhood‐Onset Lupus: A Randomized Clinical Trial

Arthritis Care &Research, EarlyView.
Objective Our objective was to determine the feasibility and acceptability of the Treatment and Education Approach for Childhood‐Onset Lupus (TEACH), a six‐session cognitive behavioral intervention addressing depressive, fatigue, and pain symptoms, delivered remotely to individual youth with lupus by a trained interventionist.
Natoshia R. Cunningham, Thea Senger‐Carpenter, Jocelyn Zuckerman, Michelle Adler, Mallet R. Reid, Ashley Danguecan, Luana Flores Pereira, Sarah I. Mossad, Samantha L. Ely, Khalid Abulaban, Elizabeth A. Kessler, Natalie Rosenwasser, Tamar B. Rubinstein, Ekemini A. Ogbu, Emily A. Smitherman, Alaina Miller, Taylor Abounader, Elizabeth Ross, Livie Timmerman, Dhriti Sharma, Jennifer N. Stinson, Stacy Allen, Kabita Nanda, Tala El Tal, Deborah M. Levy, Linda T. Hiraki, Hermine I. Brunner, Mathew Reeves, Steven J. Pierce, Andrea Knight   +29 more
wiley   +1 more source

Climate Change [PDF]

Journal of Human Lactation, 2014
openaire   +4 more sources