Results 211 to 220 of about 16,680,932 (313)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Geospatial Patterns of Non-Melanoma Skin Cancer in Relation to Climate Changes in Iran. [PDF]

Asian Pac J Cancer Prev
Aryan Kya M.
europepmc   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Intrapopulation germinability may help the Mediterranean plant species Poterium spinosum L. to cope with climate changes and landscape fragmentation. [PDF]

Sci Rep
Bonanno G, Veneziano V.
europepmc   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Climate change and interconnected risks to sustainable development in the Mediterranean

Nature Climate Change, 2018
W. Cramer, J. Guiot, Marianela Fader, J. Garrabou, Jean-Pierre Gattuso, A. Iglesias, M. Lange, P. Lionello, M. Llasat, S. Paz, J. Peñuelas, M. Snoussi, A. Toreti, M. Tsimplis, E. Xoplaki   +14 more
semanticscholar   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Corals and Reef‐Dwelling Fish Regulate Carbon Storage and Cycling Processes in Coral Reef Ecosystems

Advanced Science, EarlyView.
Coral reefs are biodiversity hotspots, yet their role in carbon storage and cycling remains poorly understood. Using field surveys and modeling in the South China Sea, we reveal the overlooked potential of carbon storage in reef ecosystems and how reef fish, corals, and surface sediment jointly shape reef carbon reservoirs.
Yiting Chen, Wenliang Zhou, Lan Qiu, Han Lai, Mingpan Huang, Qian Li, Wen Yu, Pei‐Yuan Qian, Fuwen Wei   +8 more
wiley   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Predictability of biomass burning in response to climate changes

, 2012
A. Daniau, Patrick J. Bartlein, S. Harrison, I. Prentice, Scott J. Brewer, P. Friedlingstein, T. I. Harrison-Prentice, J. Inoue, K. Izumi, J. Marlon, S. Mooney, Mitchel J Power, J. Stevenson, W. Tinner, M. Andrič, J. Atanassova, H. Behling, M. Black, O. Blarquez, K. Brown, C. Carcaillet, E. Colhoun, D. Colombaroli, B. Davis, D. D'costa, J. Dodson, L. Dupont, Zewdu Eshetu, D. Gavin, A. Genries, S. Haberle, D. Hallett, G. Hope, S. Horn, T. G. Kassa, Fumitaka Katamura, Lisa M. Kennedy, P. Kershaw, S. Krivonogov, C. Long, D. Magri, E. Marinova, G. Mckenzie, P. Moreno, P. Moss, F. Neumann, E. Norström, C. Paitre, Damien Rius, N. Roberts, G. Robinson, Naoko Sasaki, L. Scott, H. Takahara, V. T. Terwilliger, F. Thevenon, R. Turner, V. Valsecchi, B. Vannière, M. Walsh, N. Williams, Yongjun Zhang   +61 more
semanticscholar   +1 more source