Results 241 to 250 of about 93,806 (299)

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Rethinking professional boundaries: the climate crisis and brain health. [PDF]

BJPsych Bull
Conroy RM, Golden J, Malone C, Irish Doctors for the Environment.   +3 more
europepmc   +1 more source

Climate change and the agriculture crisis : agroecology as a solution

, 2015
Laxmi T, Parul
core  

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Preparing Physicians for the Climate Crisis: Next Steps for the Graduate Medical Education Community. [PDF]

J Grad Med Educ
Philipsborn R, Tuck MG, Cooney T, Colbert CY.   +3 more
europepmc   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Midwives: Essential guardians in the climate crisis journey. [PDF]

Eur J Midwifery
Ganapathy D, Tzeli M, Vivilaki V.
europepmc   +1 more source

Longitudinal determinants of thriving in Puerto Rican climate crisis migrants on the U.S. mainland: A structural equation model. [PDF]

Soc Sci Med
Duque M, Vo DH, Montero-Zamora P, Cobb CL, Sahbaz S, Ertanir B, Bautista T, Watkins LG, Acaf Y, Macias MA, Alpysbekova A, Garcia MF, Rodriguez J, Bates MM, Calderon IA, Maldonado-Molina MM, Bartholomew JB, Pinedo M, Lee TK, Salas-Wright CP, Schwartz SJ.   +20 more
europepmc   +1 more source

The ClimaQ Study: Exploring Parental Accounts of Climate Crisis-Related Emotional Responses, Awareness, and Engagement in Actions Among Children in Greece. [PDF]

Children (Basel)
Magklara K, Kapsimalli E, Vlassopoulos C, Liarakou G, Lazaratou E.   +4 more
europepmc   +1 more source

A narrative review of the current available literature on the intersection between the climate crisis and paediatric surgical care. [PDF]

Pediatr Surg Int
Patel K, Ossig A, Kudsk-Iversen S.
europepmc   +1 more source