Results 41 to 50 of about 573,597 (351)
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Brexit and the EU in Global Climate Governance [PDF]
, 2019 Climate change governance is one of the EU’s priorities. The EU has developed a central (and arguably, a leading) role in global climate governance. The UK has been an important supporter of strong climate action both within the EU and in international ...
Dupont, Claire, Moore, Brendan
core +4 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Strengthening the role of civil society in water sector governance towards climate change adaptation in African cities – Durban, Maputo, Nairobi [PDF]
, 2013 Water resources management is one of the most important climate change-related issues on international, national and urban public policy agendas. Income inequality in South Africa, Mozambique, and Kenya is among the largest in the world; in all three ...
Figueiredo, P +3 more
core
Holistic and leadership approaches to international regulation: confronting nature conservation and developmental challenges. A response to Farnese [PDF]
, 2014 International nature protection law has developed without a coherent plan, with disparate governance instruments each largely evolving within their own separate sphere.
Charnovitz, Robin, Stephenson
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
SystemsThe capacity for climate governance is crucial for sustainable advancement, with data elements being a pivotal production factor in contemporary governance.
Huwei Wen, Keyu Hu, Fengxiu Zhou
doaj +1 more source
Building or stumbling blocks? Assessing the performance of polycentric energy and climate governance networks [PDF]
, 2018 Polycentric governance networks are on the rise in global energy and climate governance, but we know surprisingly little about their effectiveness. This paper analyzes the performance of four such transnational energy and climate governance networks.
Sovacool, Benjamin K +1 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source