Results 71 to 80 of about 573,597 (351)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Climate change governance [PDF]

Climate change governance poses difficult challenges for contemporary political/administrative systems. These systems evolved to handle other sorts of problems and must now be adapted to handle emerging issues of climate change mitigation and adaptation.
Meadowcroft, James
core  

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Twenty priorities for future social-ecological research on climate resilience

Environmental Research Letters, 2020
Faced with the global climate crisis and the inevitability of future climate shocks, enhancing social-ecological resilience has become an urgent area for research and policy internationally.
Emilie Beauchamp, Mark Hirons, Katrina Brown, EJ Milner-Gulland   +3 more
doaj   +1 more source

Praxis Mapping: A methodology for evaluating the political impacts of international projects [PDF]

, 2012
This report describes the participatory development of a process we have used to consider the political implications of a climate justice project we worked on together from 2010 to 2013, called Strengthening the role of civil society in water sector ...
Bilal, S., Bond, P., Kaara, W., Khumalo, D., Manjate, E., Matavel, N., Perkins, Patricia E. (Ellie)   +6 more
core  

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Cosmopolitan Risk Community and China's Climate Governance [PDF]

, 2015
Ulrich Beck asserts that global risks, such as climate change, generate a form of ‘compulsory cosmopolitanism’, which ‘glues’ various actors into collective action.
Albrow M, Anderson B, Bai H, Beck U, Beck U, Bradsher K, Bradsher K, Chen Z, China Greentech Initiative, Crenshaw K, Economist, Favell A, Feng J, Gou H, Griffiths S, Held D, Liu X, Macur J, Ong A, Swartz S, Tschang C, Urry J, Wang J, Wu T, Yang G, Yuval-Davis N, Zhang J Y, Zhang J Y, Zhang J Y   +28 more
core   +1 more source

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) Network investigators   +14 more
wiley   +1 more source

Baku Climate Conference and the Fragmentation of Global Climate Governance

China Quarterly of International Strategic Studies
The Baku Climate Conference (COP29) is intended to address the intensifying fragmentation of global climate governance by setting new collective quantified goals (NCQGs) for climate finance and discussing critical issues such as loss and damage funds. At
Hongyuan Yu
doaj   +1 more source

Accountability in Climate change governance and Caribbean SIDS [PDF]

, 2016
Accountability is part of the good governance of institutions and regimes. The subject of this paper is nature of accountability in the climate change governance relationships.
Scobie, Michelle
core   +1 more source